Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer's Disease.
Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer's Disease.
复制标题
细胞因子信号传导抑制剂 3：中枢胰岛素抵抗和阿尔茨海默病之间的新作用。
DOI：
10.3389/fnins.2018.00417
复制
发表时间：
2018
影响因子：
4.3
通讯作者：
Wan W
中科院分区：
文献类型：
--
作者：
Cao L;Wang Z;Wan W
目前，阿尔茨海默病（AD）的病因仍不清楚。中枢胰岛素抵抗已被确定在 AD 的进展中发挥重要作用。然而，AD 中胰岛素信号通路破坏的机制尚不清楚。细胞因子信号传导抑制因子 3 (SOCS3) 是 SOCS 蛋白家族的成员，在敏感组织（如肝细胞和脂肪细胞）中充当胰岛素信号传导的负调节剂。然而，人们对其在神经系统疾病中的作用知之甚少。最近的证据表明，AD 患者大脑中 SOCS3 的水平升高，尤其是在β淀粉样蛋白沉积的区域，这表明 SOCS3 可能调节 AD 中的中枢胰岛素信号传导通路。在这里，我们讨论了SOCS3在AD中的潜在作用，并推测SOCS3可能是治疗AD的一个有前景的治疗靶点。
Currently, the etiology of Alzheimer’s disease (AD) is still elusive. Central insulin resistance has been determined to play an important role in the progress of AD. However, the mechanism underlying the development of disrupted insulin signaling pathways in AD is unclear. Suppressor of cytokine signaling 3 (SOCS3) is a member of the SOCS protein family that acts as a negative modulator of insulin signaling in sensitive tissues, such as hepatocytes and adipocytes. However, little is known about its role in neurological diseases. Recent evidence indicates that the level of SOCS3 is increased in the brains of individuals with AD, especially in areas with amyloid beta deposition, suggesting that SOCS3 may regulate the central insulin signaling pathways in AD. Here, we discuss the potential role of SOCS3 in AD and speculate that SOCS3 may be a promising therapeutic target for the treatment of AD.
登录
查看更多内容
影响因子：
16.2
作者：
Ghanim H;Abuaysheh S;Sia CL;Korzeniewski K;Chaudhuri A;Fernandez-Real JM;Dandona P
通讯作者：
Dandona P
影响因子：
--
作者：
Craft, Suzanne;Baker, Laura D.;Montine, Thomas J.;Minoshima, Satoshi;Watson, G. Stennis;Claxton, Amy;Arbuckle, Matthew;Callaghan, Maureen;Tsai, Elaine;Plymate, Stephen R.;Green, Pattie S.;Leverenz, James;Cross, Donna;Gerton, Brooke
通讯作者：
Gerton, Brooke
DOI：
10.1016/s0140-6736(16)31275-2
发表时间：
2016-12-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Gauthier S;Feldman HH;Schneider LS;Wilcock GK;Frisoni GB;Hardlund JH;Moebius HJ;Bentham P;Kook KA;Wischik DJ;Schelter BO;Davis CS;Staff RT;Bracoud L;Shamsi K;Storey JM;Harrington CR;Wischik CM
通讯作者：
Wischik CM
影响因子：
4
作者：
Claxton, Amy;Baker, Laura D.;Craft, Suzanne
通讯作者：
Craft, Suzanne
影响因子：
3.4
作者：
Cowan CM;Mudher A
通讯作者：
Mudher A