Effects of chondroitin sulfate B on the reconstitution of collagen fibrils

Effects of chondroitin sulfate B on the reconstitution of collagen fibrils
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DOI：
10.1299/transjsme.16-00343
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发表时间：
2017
期刊：
--
影响因子：
--
通讯作者：
N. Yamamoto;K. Sasaki
N. Yamamoto;K. Sasaki
中科院分区：
其他
文献类型：
--
作者：
N. Yamamoto;K. Sasaki

文献摘要

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从I型胶原蛋白溶液中体外重建胶原原纤维。胶原原纤维与硫酸软骨素B交替沉积。用石英晶体微天平（QCM）测定胶原原纤维和硫酸软骨素B的吸附质量，用原子力显微镜（AFM）观察其微观结构。胶原原纤维与硫酸软骨素B交替吸附时，胶原原纤维的吸附重量显著大于仅吸附胶原原纤维时的吸附重量。在胶原原纤维表面观察到硫酸软骨素B的吸附。上述结果表明，硫酸软骨素B对胶原原纤维的重建有一定的作用。
Collagen fibrils were reconstituted in vitro from type I collagen solution. The reconstituted collagen fibrils and chondroitin sulfate B were deposited alternately. The adsorbed weight of the collagen fibrils and chondroitin sulfate B was measured using a quartz crystal microbalance (QCM) and their microstructure was observed using an atomic force microscope (AFM). The adsorbed weight of the collagen fibrils on the adsorption of collagen fibrils and chondroitin sulfate B alternately was significantly larger than that on the adsorption of collagen fibrils only. The adsorption of chondroitin sulfate B was observed on the surfaces of collagen fibrils. These results indicate that chondroitin sulfate B is effective on the reconstitution of collagen fibrils.