Novel functions of endocytic player clathrin in mitosis
Novel functions of endocytic player clathrin in mitosis
复制标题
内吞型网格蛋白在有丝分裂中的新功能
DOI：
10.1038/cr.2011.106
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发表时间：
2011-12-01
期刊：
影响因子：
44.1
通讯作者：
Zhang, Chuanmao
中科院分区：
文献类型：
--
作者：
Fu, Wenxiang;Jiang, Qing;Zhang, Chuanmao
网格蛋白是细胞内吞过程中的一个重要参与者，它与多种衔接子和辅助蛋白有关。最近的研究表明，网格蛋白也是细胞分裂所必需的。本文主要就网格蛋白依赖的纺锤体组装和染色体排列机制进行综述。在有丝分裂中，网格蛋白与磷酸化的TACC 3形成复合物，以确保纺锤体稳定性和正确的染色体对齐。有丝分裂中网格蛋白的调控机制需要网格蛋白、纺锤体组装因子、Ran-GTP和有丝分裂激酶之间的相互作用。同时，网格蛋白在胞吞和有丝分裂过程中的角色转换需要一个协调的机制。总之，除了胞吞作用之外，网格蛋白的多种功能的发现扩展了我们对基本细胞活动的理解。
Clathrin has been widely recognized as a pivotal player in endocytosis, in which several adaptors and accessory proteins are involved. Recent studies suggested that clathrin is also essential for cell division. Here this review mainly focuses on the clathrin-dependent mechanisms involved in spindle assembly and chromosome alignment. In mitosis, clathrin forms a complex with phosphorylated TACC3 to ensure spindle stability and proper chromosome alignment. The clathrin-regulated mechanism in mitosis requires the crosstalk among clathrin, spindle assembly factors (SAFs), Ran-GTP and mitotic kinases. Meanwhile, a coordinated mechanism is required for role transitions of clathrin during endocytosis and mitosis. Taken together, the findings of the multiple functions of clathrin besides endocytosis have expanded our understanding of the basic cellular activities.