Encoding and decoding of overlapping odor sequences
Encoding and decoding of overlapping odor sequences
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DOI：
10.1016/j.neuron.2006.07.018
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发表时间：
2006-08-17
期刊：
影响因子：
16.2
通讯作者：
Laurent, Gilles
中科院分区：
文献类型：
--
作者：
Broome, Bede M.;Jayaraman, Vivek;Laurent, Gilles
气味会唤起蝗虫触角叶投射神经元（PNs）--二尖瓣细胞类似物--的复杂反应。这些模式历经数百毫秒的演变，包含有关气味特征和浓度的信息。在自然界中，动物经常会在短时间内连续遇到多种气味。我们通过呈现两种不同的气味，中间间隔不同的延迟，来探索这种情况的影响。PN 集合表征跟踪刺激的变化，在某些延迟条件下，达到的状态既不对应于单独的两种气味表征，也不对应于两种气味的静态混合表征。然后，我们对 PN 的目标--凯尼恩细胞（KCs）进行了记录。它们的反应与 PN 群体的行为一致：在某些条件下，KCs 被招募，但在单一气味或混合气味刺激时并不发射。因此，PN 群的动态与历史有关，单个 KC 的反应与 PN 群中大部分 PN 输出的片断时间解码是一致的。
Odors evoke complex responses in locust antennal lobe projection neurons (PNs)-the mitral cell analogs. These patterns evolve over hundreds of milliseconds and contain information about odor identity and concentration. In nature, animals often encounter many odorants in short temporal succession. We explored the effects of such conditions by presenting two different odors with variable intervening delays. PN ensemble representations tracked stimulus changes and, in some delay conditions, reached states that corresponded neither to the representation of either odor alone nor to the static mixture of the two. We then recorded from Kenyon cells (KCs), the PNs' targets. Their responses were consistent with the PN population's behavior: in some conditions, KCs were recruited that did not fire during single-odor or mixture stimuli. Thus, PN population dynamics are history dependent, and responses of individual KCs are consistent with piecewise temporal decoding of PN output over large sections of the PN population.