11C-SCH 39166, a selective ligand for visualization of dopamine-D1 receptor binding in the monkey brain using PET.
11C-SCH 39166, a selective ligand for visualization of dopamine-D1 receptor binding in the monkey brain using PET.
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11C-SCH 39166，一种选择性配体，用于使用 PET 可视化猴脑中多巴胺-D1 受体的结合。
DOI：
10.1007/bf02244195
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发表时间：
1991
影响因子：
3.4
通讯作者：
Halldin,C
中科院分区：
文献类型：
--
作者：
Sedvall,G;Farde,L;Barnett,A;Hall,H;Halldin,C
新的选择性D_1-多巴胺受体拮抗剂SCH_(39166)被正电子发射同位素11C标记，并作为配体用于正电子发射计算机断层扫描显示食蟹猴体内D_1受体的结合。静脉注射配体后，在多巴胺受体丰富的纹状体和新皮质中记录到显着的放射性摄取，而在多巴胺受体缺乏的小脑中则没有。静脉注射大剂量D_1-多巴胺受体拮抗剂SCH_(23390)后，纹状体和新皮质的放射性摄取明显移位，但在5-HT2受体拮抗剂酮丝氨酸后无明显变化。11C-SCH_(39166)有望成为用正电子发射计算机断层扫描技术研究活体人脑D_1-多巴胺受体特性的有用工具。
The new selective D1-dopamine receptor antagonist SCH 39166 was labelled with the positron emitting isotope11C and used as ligand for visualization of dopamine-D1receptor binding in Cynomolgus monkeys by PET. After intravenous administration of the ligand a marked uptake of radioactivity was recorded in the D1-dopamine receptor-rich striatum and neocortex but not in the dopamine receptor-poor cerebellum. The uptake of radioactivity in striatum and neocortex was markedly displaced after the intravenous injection of a high dose of the D1-dopamine receptor antagonist SCH 23390 but not after the 5-HT2receptor antagonist ketanserine.11C-SCH 39166 should be a useful tool to explore D1-dopamine receptor characteristics in the living human brain by PET.