Advancing pharmacogenomics into practice.
Advancing pharmacogenomics into practice.
复制标题
将药物基因组学推进实践。
DOI：
10.1093/ajhp/zxab489
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Cobaugh,DanielJ
中科院分区：
文献类型：
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作者：
Hoffman,JamesM;Thompson,KaseyK;Cobaugh,DanielJ
使用各种患者特定因素进行个性化和优化药物治疗是药剂师长期以来的基本作用。可以促使药物治疗改变的遗传变异对于广泛使用的药物是常见的，几十年来，患者特异性遗传信息已被用于指导选定药物的使用。然而，在常规实践中，使用基因组信息作为患者特异性因素来指导药物选择和给药落后于使用其他患者特异性药代动力学和药效学因素，如肾功能和肝功能。药物基因组学仍然是一个未充分利用的策略，以优化药物的有效性，提高药物使用的安全性，并降低整体成本的护理。这期AJHP包括对ASHP关于药剂师在临床药物基因组学中作用的声明的更新。1 ASHP声明提供了该组织对某个主题的基本观点，药物基因组学在患者护理中有着广泛的应用机会，药剂师扮演着重要角色。《2021年声明》阐明了药物基因组学检测在提高患者药物相关结果方面的价值以及药剂师在领导药物基因组学项目跨专业实施方面的作用的明确愿景。药剂师对患者的药物治疗结果和其组织中的整个药物使用系统负责。2 ASHP报表的结构分为这两个层次。首先，药剂师提供的全面药物管理应包括基因组信息。此外，药剂师具有独特的能力和定位，可以发挥领导作用，在个人和人群层面的实践环境中协同实施药物基因组学。
Individualizing and optimizing medication therapy using a variety of patient-specific factors is a longstanding and fundamental role for pharmacists. Genetic variation that can prompt changes in drug therapy is common for widely used medications, and for decades patient-specific genetic information has been utilized to guide the use of selected medications. However, in routine practice, using genomic information as a patient-specific factor to guide medication selection and dosing lags behind use of other patient-specific pharmacokinetic and pharmacodynamic factors such as renal and hepatic function. Pharmacogenomics remains an underused strategy to optimize medication effectiveness, improve medicationuse safety, and reduce overall costs of care. This issue of AJHP includes an update to ASHP’s Statement on the Pharmacist’s Role in Clinical Pharmacogenomics. 1 ASHP statements provide the organization’s fundamental views on a topic, and pharmacogenomics has rich opportunities for wider use in patient care, with an important role for pharmacists. The 2021 Statement articulates a clear vision regarding the value of pharmacogenomic testing in enhancing patients’ medication-related outcomes and pharmacists’ roles in leading interprofessional implementation of pharmacogenomics programs.Pharmacists are responsible and accountable for patients’ drug therapy outcomes and the entire medication-use system in their organizations. 2 The ASHP Statement is structured at these two levels. First, pharmacist-provided comprehensive medication management should incorporate genomic information. Further, pharmacists are uniquely capable and positioned to take a leadership role to collaboratively implement pharmacogenomics in their practice settings at the individual and population levels.