Stereotactic body radiation therapy for Japanese patients with localized prostate cancer: 2-year results and predictive factors for acute genitourinary toxicities
Stereotactic body radiation therapy for Japanese patients with localized prostate cancer: 2-year results and predictive factors for acute genitourinary toxicities
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DOI：
10.1093/jjco/hyab094
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发表时间：
2021-06-15
影响因子：
2.4
通讯作者：
Okuda, Takahito
中科院分区：
文献类型：
--
作者：
Ito, Makoto;Yoshioka, Yasuo;Okuda, Takahito
目的：我们的目的是报告2年的结果，立体定向体放射治疗前列腺癌，并确定预测急性泌尿生殖系统toxics.Methods的临床和剂量学因素：我们回顾性地审查了2017年和2020年之间在丰田纪念医院治疗的非转移性前列腺癌患者的病历。患者接受立体定向放射治疗，总剂量为36.25戈伊，分5次，连续工作日。虽然低风险患者接受放疗单独，中，高风险患者也接受雄激素剥夺therapy.Results：我们分析了104例患者，包括10，60和34低，中，高风险患者，分别。中位随访时间为2年。我们没有观察到生化/临床复发，远处转移或前列腺癌死亡。一名患者死于其他原因。在40例（38%）患者中观察到2级急性泌尿生殖系统毒性。年龄（P = 0.021）、基线时泌尿生殖系统毒性≥ 1级（P = 0.023）和膀胱平均剂量（P = 0.047）与2级急性泌尿生殖系统毒性的发生率显著相关。年龄的截止值65岁和膀胱平均剂量的截止值10.3戈伊被认为是最合适的。在5例（5%）患者中观察到2级急性胃肠道毒性。没有一个患者出现>= 3级的急性或晚期毒性。结论：立体定向放射治疗对日本前列腺癌患者是可行的，急性毒性可以接受。年龄、基线泌尿生殖系统毒性和膀胱平均剂量可预测2级急性泌尿生殖系统毒性。
Objective: We aimed to report the 2-year results of stereotactic body radiation therapy for prostate cancer and identify the clinical and dosimetric factors that predict acute genitourinary toxicities.Methods: We retrospectively reviewed the medical records of patients with non-metastatic prostate cancer treated at Toyota Memorial Hospital between 2017 and 2020. The patients were treated with stereotactic body radiation therapy with a total dose of 36.25 Gy in five fractions on consecutive weekdays. While low-risk patients received radiotherapy alone, intermediate- to high-risk patients also received androgen deprivation therapy.Results: We analysed a total of 104 patients, including 10, 60 and 34 low-, intermediate- and high-risk patients, respectively. The median follow-up duration was 2 years. We did not observe biochemical/clinical recurrence, distant metastasis or death from prostate cancer. One patient died of another cause. Grade 2 acute genitourinary toxicity was observed in 40 (38%) patients. Age (P = 0.021), genitourinary toxicity of grade >= 1 at baseline (P = 0.023) and bladder mean dose (P = 0.047) were significantly associated with the incidence of grade 2 acute genitourinary toxicity. The cut-off value of 65 years for age and 10.3 Gy for the bladder mean dose were considered the most appropriate. Grade 2 acute gastrointestinal toxicity was observed in five (5%) patients. None of the patients experienced grade >= 3 acute or late toxicity.Conclusions: Stereotactic body radiation therapy is feasible for Japanese patients with prostate cancer, with acceptable acute toxicity. Age, genitourinary toxicity at baseline and bladder mean dose predict grade 2 acute genitourinary toxicity.