Atheroarteriosclerosis induced by infection with a herpesvirus.
Atheroarteriosclerosis induced by infection with a herpesvirus.
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由疱疹病毒感染引起的动脉粥样硬化。
DOI：
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发表时间：
1979
影响因子：
6
通讯作者：
M. M. Litrenta
中科院分区：
文献类型：
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作者：
C. Minick;C. Fabricant;J. Fabricant;M. M. Litrenta
通过感染马立克氏病疱疹病毒(MDV)，在正常胆固醇血症和高胆固醇血症鸡中诱导出与人类相似的动脉粥样硬化。使用了四组大小相当的鸡。最初，每组人的饮食中胆固醇含量相对较低。I组和II组分别于2日龄气管内接种MDV。在15周时，一组感染病毒的鸡(II组)和一组未感染的对照组(IV组)被喂以2%的胆固醇补充剂，继续喂养15周。感染的I组和未感染的III组继续低胆固醇饮食。所有组在30周时处死。I组和II组的大冠状动脉、主动脉和主动脉主干均可见明显的动脉粥样硬化病变，而III组和IV组未见。显微镜下，感染动物的动脉病变以闭塞性纤维肌肉内膜增厚为特征，在动脉粥样瘤性病变的区域形成纤维帽。这种变化非常类似于人类的慢性动脉粥样硬化。这些结果可能对我们理解人类动脉硬化很重要，因为人类人群中广泛而持续地感染多达五种疱疹病毒。
Atheroarteriosclerosis closely resembling that in humans was induced in normocholesterolemic and hypercholesterolemic chickens by infection with Marek's disease herpesvirus (MDV). Four comparably sized groups of chickens were used. Each group was initially fed a diet relatively poor in cholesterol. Group I and II were inoculated intratracheally at 2 days of age with MDV. At 15 weeks, one group of virus-infected chickens (Group II) and one group of uninfected controls (Group IV) were fed a 2% cholesterol supplement for an additional 15 weeks. Group I, infected, and III, uninfected, were continued on a cholesterol-poor diet. All groups were killed at 30 weeks. Striking grossly visible atherosclerotic lesions were seen in large coronary arteries, aortas, and major aortic branches of both Groups I and II but not in those of Groups III and IV. Microscopically, arterial changes in infected animals were characterized by occlusive fibromuscular intimal thickening, which formed fibrous caps overlying areas of atheromatous change. This change closely resembled chronic atherosclerosis in humans. These results may be important to our understanding of human arteriosclerosis, since there is widespread and persistent infection of human populations with as many as five herpesviruses.