Epigenetic regulation of hematopoietic stem cell self-renewal by Polycomb group genes
Epigenetic regulation of hematopoietic stem cell self-renewal by Polycomb group genes
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DOI：
10.1532/ijh97.05011
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发表时间：
2005-05-01
影响因子：
2.1
通讯作者：
Nakauchi, H
中科院分区：
文献类型：
--
作者：
Iwama, A;Oguro, H;Nakauchi, H
Polycomb group（PcG）基因通过表观遗传染色质修饰参与细胞记忆的维持。最近的研究表明，PcG基因在造血干细胞（HSC）的自我更新中发挥作用，这是一个通过细胞分裂维持细胞记忆的过程。在PcG基因中，Bmi-1在干细胞遗传中起核心作用，其强制表达促进HSC自我更新。这些发现强调了表观遗传调控在HSC自我更新中的重要性，并将PcG基因确定为治疗性HSC操纵的潜在靶点。(c)2005日本血液学会。
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of sternness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. (c) 2005 The Japanese Society of Hematology.