High incidence of in-transit metastases after sentinel node biopsy in patients with melanoma
High incidence of in-transit metastases after sentinel node biopsy in patients with melanoma
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DOI：
10.1002/bjs.4692
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发表时间：
2004-10-01
影响因子：
9.6
通讯作者：
Kroon, BBR
中科院分区：
文献类型：
--
作者：
Estourgie, SH;Nieweg, OE;Kroon, BBR
背景：肿瘤阳性前哨淋巴结患者的转运转移发生率在不同的中心差异很大，有研究表明该患者组的发病率很高。方法：比较61例因前哨淋巴结阳性而行淋巴结清扫的患者与60例可触及淋巴结清扫的患者的转移发生率。结果：前哨淋巴结阳性患者转运转移发生率为23%，可触及淋巴结患者转运转移发生率为8% （P = 0.027）。结论：前哨淋巴结活检与更高的转移风险相关。这一发现不支持在黑色素瘤治疗中常规使用前哨淋巴结活检。
Background: The occurrence of in-transit metastases in patients with a tumour-positive sentinel node varies greatly between centres and it has been suggested that the incidence is high in this patient group.Methods: The incidence of in-transit metastases in 61 patients who had lymph node dissection because of a tumour-positive sentinel node was compared with that in 60 patients who had palpable nodal metastases dissected.Results: The incidence of in-transit metastases was 23 per cent in patients with a positive sentinel node and 8 per cent in those with palpable nodes (P = 0.027).Conclusion: Sentinel node biopsy was associated with a higher risk of in-transit metastases. This finding does not support the routine use of sentinel node biopsy in the management of melanoma.