POSTPRANDIAL PLASMA GLUCOSE, INSULIN, GLUCAGON AND TRIGLYCERIDE RESPONSES TO A STANDARD DIET IN NORMAL SUBJECTS
POSTPRANDIAL PLASMA GLUCOSE, INSULIN, GLUCAGON AND TRIGLYCERIDE RESPONSES TO A STANDARD DIET IN NORMAL SUBJECTS
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DOI：
10.1007/bf01221966
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发表时间：
1976-01-01
期刊：
影响因子：
8.2
通讯作者：
NUTTALL, FQ
中科院分区：
文献类型：
--
作者：
AHMED, M;GANNON, MC;NUTTALL, FQ
对12名正常受试者（7男5女）进行餐后血糖、胰岛素和甘油三酯反应的测定。这三顿饭对每个受试者来说都是一样的。观察到餐后血糖和胰岛素显著升高。在吸收后早期，它们在时间上密切相关。在吸收后晚期，胰岛素的下降通常比葡萄糖的下降慢。葡萄糖和胰岛素反应在男性和女性之间有相当大的差异，女性空腹血糖和胰岛素浓度较低。每顿饭后，女性的血糖峰值都较低，但只有早餐后差异才显著（P < 0.02）。女性早餐后血糖曲线下面积也较低（P < 0.01）。在男性中，餐后最大葡萄糖浓度和餐后葡萄糖面积全天保持稳定，但胰岛素浓度和胰岛素面积峰值在晚餐后有所增加。在女性中，餐后最大葡萄糖浓度和餐后葡萄糖面积全天都在增加，但胰岛素峰值浓度和胰岛素面积没有变化。血浆甘油三酯在早餐时升高，并在一天中保持升高。男性的空腹和餐后甘油三酯平均值都较高，但没有达到统计学意义。4名受试者的循环胰高血糖素浓度不受饮食影响，全天保持稳定。
Postprandial plasma glucose, insulin and triglyceride responses were determined in 12 normal subjects (7 male and 5 female) fed a standard diet composed of typical American foods; the 3 meals were identical for each subject. A significant postprandial rise in glucose and insulin was observed. They were closely related temporally in the early post-absorptive period. In the late post-absorptive phase insulin decline was generally slower than the glucose decline. A considerable difference in the glucose and insulin response was observed between males and females with fasting plasma glucose and insulin concentrations lower in the women. Following each meal the peak plasma glucose was lower in women, but the difference was significant only following breakfast (P < 0.02). The area under the glucose curve following breakfast was also lower (P < 0.01) in the women. In the men the maximal postprandial glucose concentration and the postprandial glucose area remained stable throughout the day, but there was an increase in peak insulin concentration and insulin area after dinner. In the women the maximal postprandial glucose concentration and the postprandial glucose area increased throughout the day, but the peak insulin concentration and insulin area did not change. Plasma triglycerides increased with breakfast and remained elevated throughout the day. Both fasting and postprandial mean triglycerides were higher in the men, but this did not reach statistical significance. The circulating pancreatic glucagon concentration, determined in 4 subjects, was unaffected by meals and remained stable throughout the day.