Resveratrol Cardioprotection Against Myocardial Ischemia/Reperfusion Injury Involves Upregulation of Adiponectin Levels and Multimerization in Type 2 Diabetic Mice
Resveratrol Cardioprotection Against Myocardial Ischemia/Reperfusion Injury Involves Upregulation of Adiponectin Levels and Multimerization in Type 2 Diabetic Mice
复制标题
白藜芦醇对心肌缺血/再灌注损伤的心脏保护作用涉及 2 型糖尿病小鼠脂联素水平的上调和多聚化
DOI：
10.1097/fjc.0000000000000417
复制
发表时间：
2016-10
影响因子：
3
通讯作者：
Tao Ling
中科院分区：
文献类型：
--
作者：
Yang Qiang;Wang Hai chang;Liu Yi;Gao Chao;Sun Lu;Tao Ling
Abstract: Downregulation of adiponectin (APN) multimerization is significantly correlated with the aggravation of myocardial ischemia/reperfusion (MI/R) injury in type 2 diabetes mellitus (T2DM). Resveratrol (RSV) upregulates APN multimerization in adipocytes, but whether RSV improves endogenous APN multimerization and thus attenuates MI/R injury in T2DM mice has never been investigated. T2DM mice were treated with 10 mg/kg RSV daily for 3 weeks, followed by 30 minutes of myocardial ischemia and 3 hours or 24 hours of reperfusion. RSV administration alleviated MI/R injury in diabetic mice, as evidenced by reduced infarct size, cardiomyocyte apoptosis, and caspase-3 activity, and improved cardiac function. Moreover, RSV reversed the downregulated APN levels and multimerization both in plasma and adipose tissue, accompanied by increased disulfide bond A oxidoreductase-like protein (DsbA-L) expression in T2DM mice. Conversely, serving as a key downstream molecule of APN in ameliorating MI/R injury, inhibition of AMP-activated protein kinase (AMPK) significantly attenuated the cardioprotective effects of RSV. In conclusion, long-term administration of RSV upregulates adiponectin levels and multimerization in T2DM mice, consequently attenuating MI/R injury partially through APN-AMPK signaling.
登录
查看更多内容
DOI：
10.2174/157489007780832560
发表时间：
2007-05
期刊：
Recent patents on cardiovascular drug discovery
影响因子：
--
作者：
Samarjit Das;D. Das
通讯作者：
Samarjit Das;D. Das
影响因子：
6.6
作者：
Liu, Yi;Ma, Yanzhuo;Tao, Ling
通讯作者：
Tao, Ling
影响因子：
4.8
作者：
Waki, H;Yamauchi, T;Kadowaki, T
通讯作者：
Kadowaki, T
影响因子：
82.9
作者：
Yamauchi, T;Kamon, J;Kadowaki, T
通讯作者：
Kadowaki, T
影响因子：
3.4
作者：
Akar, Fatma;Pektas, M. Bilgehan;Surucu, H. Selcuk
通讯作者：
Surucu, H. Selcuk