STUDIES ON THE MECHANISM OF HYPERSENSITIVITY PHENOMENA
STUDIES ON THE MECHANISM OF HYPERSENSITIVITY PHENOMENA
复制标题
超敏现象发生机制的研究
DOI：
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发表时间：
1957
影响因子：
15.3
通讯作者：
O. Bier
中科院分区：
文献类型：
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作者：
A. G. Osler;M. M. Hawrisiak;Z. Óváry;M. Siqueira;O. Bier
描述了实验，表明正常大鼠对给定水平的免疫试剂的被动皮肤过敏反应（PCA）反应的幅度和灵敏度，可以通过加入溶血活性血清来增强。用具有与C '的第三组分相关的性质的C'组分试剂在正常大鼠中获得了类似的增强。显示了C'的体外固定与抗原和抗体诱导PCA之间的相似性。马抗肺炎球菌系统具有低的C '-固定效力，并且在PCA的诱导中也比兔多糖系统效率低。在兔抗核糖核酸酶与核糖核酸酶（该酶的乙酰化和胍基化衍生物）的反应中观察到类似性质的发现。将溶血活性血清注射到C '缺乏大鼠中，伴随着PCA的部分恢复。恢复效果也注意到加热和氨处理的血清。在C '耗尽的大鼠中，溶血效力和对PCA的反应性的恢复遵循类似的时间过程。所提供的数据表明，PCA反应可以作为至少三个变量的函数来研究，这三个变量是抗原、抗体和类似于C '的血清成分。
Experiments are described indicating that the magnitude and sensitivity of the passive cutaneous anaphylaxis (PCA) response in normal rats to a given level of immune reagents, may be enhanced by the addition of hemolytically active sera. A similar enhancement in normal rats has been obtained with C' component reagents possessing properties associated with the third component of C'. Parallelisms between in vitro fixation of C' and PCA induction by antigen and antibody are shown. The horse anti-pneumococcus system has low C'-fixing potencies and is also less efficient than the rabbit polysaccharide system in the induction of PCA. Findings of a similar nature were observed in the reaction of rabbit anti-ribonuclease with ribonuclease, the acetylated and guanidinated derivatives of the enzyme. The injection of hemolytically active serum into C'-deficient rats was accompanied by a partial restoration of PCA. Restorative effects were also noted with heated and ammonia-treated serum. The return of hemolytic potency and responsiveness to PCA in C'-depleted rats, follow a similar time course. The data presented indicate that the PCA reaction can be studied as a function of at least three variables, antigen, antibody, and a serum constituent resembling C'.