The Synthesis and Physical Properties of Novel Polyaromatic Profluorescent Isoindoline Nitroxide Probes
The Synthesis and Physical Properties of Novel Polyaromatic Profluorescent Isoindoline Nitroxide Probes
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DOI：
10.1002/ejoc.200800597
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发表时间：
2008-11-01
影响因子：
2.8
通讯作者：
Bottle, Steven E.
中科院分区：
文献类型：
--
作者：
Fairfull-Smith, Kathryn E.;Bottle, Steven E.
通过钯催化的Suzuki偶联和Sonogashira偶联反应合成了新的含9，10-二苯基蒽和9，10-双（苯乙炔基）蒽结构核的单和双异吲哚啉氮氧化合物（5，11，16和19）。这些氮氧自由基荧光探针具有强烈的抑制荧光，即使在只有一个氮氧自由基的存在下。在还原或与其他自由基反应时，返回正常的荧光发射。氮氧自由基及其相应的抗磁性类似物之间的荧光输出的显着差异，使这些探针的理想工具，使用荧光显微镜成像聚合物降解。（（C）Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2008）
New profluorescent mono- and di-isoindoline nitroxides (5, 11, 16 and 19) containing 9,10-diphenylanthracene and 9,10-bis(phenylethynyl)anthracene structural cores were synthesised by palladium-catalysed Suzuki and Sonogashira couplings. These nitroxide-fluorophore probes possess strongly suppressed fluorescence, even in the presence of only one nitroxide radical. Upon reduction, or reaction with other radicals, normal fluorescence emission is returned. The significant difference in fluorescence output between the nitroxides and their corresponding diamagnetic analogues makes these probes ideal tools for imaging polymer degradation using fluorescence microscopy. ( (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)