ORAL ALLERGY SYNDROME - THE EFFECT OF ASTEMIZOLE
ORAL ALLERGY SYNDROME - THE EFFECT OF ASTEMIZOLE
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DOI：
10.1111/j.1398-9995.1991.tb00631.x
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发表时间：
1991-11-01
期刊：
影响因子：
12.4
通讯作者：
WEEKE, B
中科院分区：
文献类型：
--
作者：
BINDSLEVJENSEN, C;VIBITS, A;WEEKE, B
研究了阿司咪唑（Hismanal（R））治疗对桦树花粉过敏患者摄入榛子引起的症状（口腔过敏综合征）的影响。研究纳入了30例对银桦树有充分记录的过敏，在摄入榛子时出现症状的患者。所有人对桦树的皮肤点刺试验（SPT）均呈阳性，而分别有29人和27人对桦树的RAST和嗜碱性细胞组胺释放试验（HR）呈阳性。与此相反，只有15例患者有一个积极的SPT榛子，13个有一个积极的RAST，而24个有一个积极的HR. After两个口服挑衅与榛子的患者随机接受阿司咪唑或安慰剂，每天10毫克，2周的双盲协议，随后两个口服挑衅。与安慰剂相比，阿司咪唑治疗显著减轻了症状（P = 0.004）;然而，没有完全消除症状。
The effect of treatment with astemizole (Hismanal(R)) on symptoms elicited by ingestion of hazelnuts in birch pollen-allergic patients (the oral allergy syndrome) was investigated, Thirty patients with a well-documented allergy to silver birch, experiencing symptoms when ingesting hazelnuts, were included in the study. All had a positive skin prick test (SPT) to birch, whereas 29 and 27, respectively, showed a positive RAST and basophil histamine release test (HR) to birch. In contrast, only 15 patients had a positive SPT to hazelnut, 13 had a positive RAST, whereas 24 had a positive HR. After two oral provocations with hazelnuts the patients were randomized to receive either 10 mg of astemizole or placebo daily for 2 weeks in a double blind protocol followed by two oral provocations. Treatment with astemizole significantly reduced the symptoms compared with placebo (P = 0.004); however, without completely abolishing the symptoms.