HEREDITARY RENAL-CELL CARCINOMA ASSOCIATED WITH A CHROMOSOMAL TRANSLOCATION
HEREDITARY RENAL-CELL CARCINOMA ASSOCIATED WITH A CHROMOSOMAL TRANSLOCATION
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DOI：
10.1056/nejm197909133011107
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
BROWN, RS
中科院分区：
文献类型：
--
作者：
COHEN, AJ;LI, FP;BROWN, RS
许多形式的人类癌症往往发生在家族中。家族性癌症的环境原因通常无法确定，通过排除，可以在系谱分析的基础上假设遗传机制。然而，已发表的关于癌症家族的染色体研究尚未发现特定的遗传性核型异常。我们将描述一个家庭与肾细胞癌和体质染色体易位。连续三代共有10名成员（5男5女）患癌。该癌症在先证者和6名亲属中出现症状，并通过筛查无症状的家庭成员在另外3人中被诊断出来。这个……
MANY forms of human cancer tend to occur in families.1Environmental causes of familial cancer often cannot be identified, and, by exclusion, a hereditary mechanism is postulated on the basis of pedigree analysis. However, published chromosomal studies of families with cancer have not identified specific inherited karyotypic abnormalities.We shall describe a family with renal-cell carcinoma and a constitutional chromosomal translocation. The cancer arose in 10 members (five men and five women) of three consecutive generations. The cancers produced symptoms in the proband and six relatives and was diagnosed in three other persons by screening of asymptomatic family members. The . . .