SUDEP, suspected positional airway obstruction, and hypoventilation in postictal coma
SUDEP, suspected positional airway obstruction, and hypoventilation in postictal coma
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DOI：
10.1111/j.1528-1167.2010.02719.x
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发表时间：
2010-11-01
期刊：
影响因子：
5.6
通讯作者：
Ebersole, John S.
中科院分区：
文献类型：
--
作者：
Tao, James X.;Qian, Shuo;Ebersole, John S.
癫痫猝死（SUDEP）是慢性癫痫患者死亡的主要原因。尽管近年来医学界和科学界对SUDEP产生了浓厚的兴趣，但其病因仍在很大程度上未得到解决。一名35岁的女性在俯卧位全身癫痫发作后发生SUDEP。她的死亡原因可能是发作后昏迷和疑似位置性气道阻塞和通气不足的汇合导致的窒息，而不是通常怀疑的发作期心律失常或中枢性呼吸暂停。SUDEP可能与婴儿猝死综合征（SIDS）有相似的病因，并且可能是可以预防的，至少在一定比例的病例中是如此。
P>Sudden unexpected death in epilepsy (SUDEP) is the leading cause of mortality in patients with chronic uncontrolled epilepsy. Despite intense interest in SUDEP from the medical and scientific communities in recent years, its etiologies are still largely unresolved. A 35-year-old woman had SUDEP after having a generalized seizure in the prone position. The cause of her death was likely asphyxia from the convergence of postictal coma and suspected positional airway obstruction and hypoventilation, rather than the commonly suspected periictal cardiac arrhythmia or central apnea. SUDEP may share a similar etiology with sudden infant death syndrome (SIDS) and is likely preventable, at least in a proportion of cases.