CORRELATION AND PROBABILITY METHODS FOR ONE AND 2 LOCI
CORRELATION AND PROBABILITY METHODS FOR ONE AND 2 LOCI
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DOI：
10.1016/0040-5809(73)90008-7
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发表时间：
1973-01-01
影响因子：
1.4
通讯作者：
FELDMAN, MW
中科院分区：
文献类型：
--
作者：
SVED, JA;FELDMAN, MW
用相关法和概率法可以得到单个位点近交系数的等价导数。两个推导之间的关系可以表示为rA = fA的形式，其中rA是在A基因座处结合配子的相关性，fA是在该基因座处的两个基因通过血统相同的概率。对于一个2-基因座的遗传模型，Sved推导出了一个表面上类似的关系[见阿坝40，5383]，他证明了rAB 2 = QAB，其中rAB是2个连锁基因座上频率的相关性，QAB是这样的概率，即，给定1个基因座上的2个基因是相同的，是从某个近或远祖先遗传而来的，第二个基因座上的基因通过相同途径的遗传是相同的。如果QAB以fAB 2的形式表示，其中fAB是单个配子在共同祖先的路径上保持完整的概率，可以看出2-位点关系完全类似于上面给出的单位点关系，因此许多针对单位点模型导出的递归关系在2-位点模型中具有精确的对应关系。
Equivalent derivations of the inbreeding coefficient for a single locus can be obtained by correlation and by probability methods. The relationship between the 2 derivations may be expressed in the form rA = fA, where rA is the correlation of uniting gametes at the A locus, and fA is the probability that the 2 genes at the locus are identical by descent. For a 2-locus diallel model, a superficially similar relationship has been derived by Sved [see ABA 40, 5383], who showed that rAB2 = QAB, where rAB is the correlation of frequencies at 2 linked loci, and QAB is the probability that, given that the 2 genes at 1 locus are identical by descent from some near or remote ancestor, the genes at the 2nd locus will be identical by descent through the same pathways. If QAB is expressed in the form fAB2, where fAB is the probability of a single gamete remaining intact on the pathway for a common ancestor, it can be seen that the 2-locus relationship is completely analogous to the single-locus relationship given above, hence many of the recurrence relationships derived for single-locus models will have an exact counterpart in 2-locus models.