A SIMPLE ESTIMATE OF GLOMERULAR-FILTRATION RATE IN ADOLESCENT BOYS
A SIMPLE ESTIMATE OF GLOMERULAR-FILTRATION RATE IN ADOLESCENT BOYS
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DOI：
10.1016/s0022-3476(85)80697-1
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发表时间：
1985-01-01
影响因子：
5.1
通讯作者：
GAUTHIER, B
中科院分区：
文献类型：
--
作者：
SCHWARTZ, GJ;GAUTHIER, B
对212名13-21岁女孩和356名男孩(包括181名男孩和69名女孩)的肌酐清除量(Ccr)与身体习惯的关系进行了复查。使用公式Ccr=k L/Pcr来计算肾小球滤过率，其中k=0.55，导致青春期男孩的肾小球滤过率被显著低估，但适用于女孩。在51名青春期男孩中，方程Ccr=0.7GFR/L/Pcr可准确估计肾小球滤过率。对133名3~21岁男童的回归分析表明，随着年龄的增长，k值呈线性递增趋势(r=0.35，P<；0.01)。以年为单位的线性二元方程Ccr=1.5(年龄)+0.5(L/Pcr)可以更好地估计任何年龄男孩的肾小球滤过率(r=0.82，P<；0.001)。在91项额外的清除研究中，这个方程式的结果略好于0.7%的L/聚合酶链式反应，研究对象是自体肾脏或功能正常的肾移植的青春期男孩。常数k(0.7)的较大值和GFR的年龄校正反映了青春期男孩单位体重的尿肌酐排泄率(因此肌肉质量)更高。
The relationship between creatinine clearance (Ccr) and body habitus was reexamined in 212 girls and 356 boys, including 181 boys and 69 girls between 13 and 21 yr of age. The use of formula Ccr = k L/Pcr, where k = 0.55 for the calculation of GFR [glomerular filtration rate] resulted in a significant underestimation of GFR in adolescent boys but was suitable for girls. In 51 adolescent boys the equation Ccr = 0.7 L/Pcr resulted in an accurate estimate of GFR. Regression analysis in 133 boys aged 3-21 yr showed that the constant k increased gradually and linearly with age (r = 0.35, P < 0.01). GFR could be better estimated for boys of any age by the linear bivariate equation Ccr = 1.5 (age) + 0.5 (L/Pcr), where age is given in years (r = 0.82, P < 0.001). This equation yielded slightly better results than did 0.7 L/Pcr in 91 additional clearance studies performed in adolescent boys with native kidneys or functioning renal transplants. The larger value for the constant k (0.7) and the age correction for GFR reflect the greater rate of urinary creatinine excretion (and thus muscle mass) per unit of body mass in adolescent boys.