Long-lived Drosophila with overexpressed dFOXO in adult fat body
Long-lived Drosophila with overexpressed dFOXO in adult fat body
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DOI：
10.1126/science.1098219
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发表时间：
2004-07-16
期刊：
影响因子：
56.9
通讯作者：
Partridge, L
中科院分区：
文献类型：
--
作者：
Giannakou, ME;Goss, M;Partridge, L
胰岛素/胰岛素样生长因子信号通路（IIS）活性降低可延长多种生物体的寿命。我们研究了减少IIS对寿命的影响的时间以及潜在靶组织脂肪体的作用。我们在成年果蝇体内过表达dFOXO，IIS的下游效应子，这增加了雌性果蝇的寿命，降低了雌性果蝇的繁殖力，但对雄性果蝇的寿命没有影响。因此，FOXO转录因子和脂肪组织的作用在衰老的调节中是进化上保守的，成年人IIS的减少足以介导其对寿命和生育力的影响。
Reduced activity of the insulin/insulin-like growth factor signaling (IIS) pathway increases life-span in diverse organisms. We investigated the timing of the effect of reduced IIS on life-span and the role of a potential target tissue, the fat body. We overexpressed dFOXO, a downstream effector of IIS, in the adultDrosophilafat body, which increased life-span and reduced fecundity of females but had no effect on male life-span. The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity.