Selective autophagy as a therapeutic target for neurological diseases.
Selective autophagy as a therapeutic target for neurological diseases.
复制标题
选择性自噬作为神经系统疾病的治疗靶点
DOI：
10.1007/s00018-020-03667-9
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Shao A
中科院分区：
文献类型：
--
作者：
Xu W;Ocak U;Gao L;Tu S;Lenahan CJ;Zhang J;Shao A
The neurological diseases primarily include acute injuries, chronic neurodegeneration, and others (e.g., infectious diseases of the central nervous system). Autophagy is a housekeeping process responsible for the bulk degradation of misfolded protein aggregates and damaged organelles through the lysosomal machinery. Recent studies have suggested that autophagy, particularly selective autophagy, such as mitophagy, pexophagy, ER-phagy, ribophagy, lipophagy, etc., is closely implicated in neurological diseases. These forms of selective autophagy are controlled by a group of important proteins, including PTEN-induced kinase 1 (PINK1), Parkin, p62, optineurin (OPTN), neighbor of BRCA1 gene 1 (NBR1), and nuclear fragile X mental retardation-interacting protein 1 (NUFIP1). This review highlights the characteristics and underlying mechanisms of different types of selective autophagy, and their implications in various forms of neurological diseases.
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影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
4.7
作者：
Babu, JR;Geetha, T;Wooten, MW
通讯作者：
Wooten, MW
影响因子：
5.3
作者：
Bandyopadhyay, Urmi;Kaushik, Susmita;Cuervo, Ana Maria
通讯作者：
Cuervo, Ana Maria
影响因子：
5.3
作者：
Carloni, Silvia;Albertini, Maria Cristina;Balduini, Walter
通讯作者：
Balduini, Walter
DOI：
10.1073/pnas.1613040114
发表时间：
2017-01-10
影响因子：
11.1
作者：
Aguirre, Jacob D.;Dunkerley, Karen M.;Shaw, Gary S.
通讯作者：
Shaw, Gary S.