Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in Swedish men
Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in Swedish men
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DOI：
10.1007/s002230020048
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发表时间：
2002-01-01
影响因子：
4.2
通讯作者：
Nilsson, AG
中科院分区：
文献类型：
--
作者：
Gillberg, P;Olofsson, H;Nilsson, AG
有关男性骨代谢激素调节的研究表明，胰岛素样生长因子-I(IGF-I)和性激素与骨密度(BMD)之间存在协同变化。本研究对55名22~85岁(平均+/-18岁，平均+/-SD)瑞典男性的全身、腰椎、股骨颈、远端和超远端(UD)骨密度与IGFS、IGFBPs和性激素水平的关系进行了研究。BMD与血清IGF-I(r=0.31~0.49)、IGF-II(r=0.32~0.48)、IGFBP-3(r=0.37~0.53)、游离雄激素指数(FAI)呈正相关(r=0.32~0.40)，与IGFBP-1(r=-0.37~-0.41)、IGFBP-2(r=-0.29~-0.41)呈负相关。股骨颈骨密度与雌二醇、SHBG比值呈正相关(r=0.34)。P=0.01)。年龄与血清IGF-I、IGF-II、IGFBP-3、FAI、雌二醇/SHBG比值呈负相关。并与IGFBP-1呈正相关。IGFBP-2。和SHBG水平。逐步多元回归分析显示，体重、胰岛素样生长因子结合蛋白-3和睾酮对股骨颈骨密度变异的贡献率为43%，远端为34%，全身为48%(P<；0.0001)。这些发现表明，性激素和IGF系统的不同组成部分与瑞典男性的BMD有关，这表明这些系统中与年龄相关的变化可能有助于老年男性骨质疏松的发展。
Studies on the hormonal regulation of bone metabolism in men have indicated covariation between insulin-like growth factor-I (IGF-I) and sex hormones with bone mineral density (BMD). In this study the relationships between BMD in total body, lumbar spine, femoral neck, distal and ultradistal (UD) radius and circulating levels of IGFs, IGF binding proteins (IGFBPs), and sex steroids were investigated in 55 Swedish men between 22 and 85 (52 +/- 18, mean +/- SD) years of age. BMD in total body, distal and UD radius, and femoral neck was positively correlated with serum IGF-I (r = 0.31 to 0.49), IGF-II (r = 0.32 to 0.48) IGFBP-3 (r = 0.37 to 0.53), and free androgen index (FAI) (r = 0.32 to 0.40), and negatively with IGFBP-1 (r = -0.37 to -0.41) and IGFBP-2 (r = -0.29 to -0.41) levels. A positive correlation was observed between BMD in femoral neck and estradiol,,SHBG ratio (r = 0.34. P = 0.01). Age correlated negatively with serum IGF-I, IGF-II, IGFBP-3, FAI, estradiol/SHBG ratio. and BMD in total body, distal and UD radius, and femoral neck, and positively with IGFBP-1. IGFBP-2. and SHBG levels. According to stepwise multiple regression analyses, a combination of weight, IGFBP-3, and testosterone accounted for 43% of the variation in BMD in femoral neck, 34% in ultradistal radius and 48% in total body (P < 0.0001). These findings indicate that sex hormones and the different components of the IGF system are associated with BMD in Swedish men, suggesting that age-related changes in these systems could contribute to the development of osteoporosis in elderly men.