ON AREAS OF TRANSITION BETWEEN ENTORHINAL ALLOCORTEX AND TEMPORAL ISOCORTEX IN THE HUMAN-BRAIN - NORMAL MORPHOLOGY AND LAMINA-SPECIFIC PATHOLOGY IN ALZHEIMERS-DISEASE
ON AREAS OF TRANSITION BETWEEN ENTORHINAL ALLOCORTEX AND TEMPORAL ISOCORTEX IN THE HUMAN-BRAIN - NORMAL MORPHOLOGY AND LAMINA-SPECIFIC PATHOLOGY IN ALZHEIMERS-DISEASE
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DOI：
10.1007/bf00690836
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发表时间：
1985-01-01
影响因子：
12.7
通讯作者：
BRAAK, E
中科院分区：
文献类型：
--
作者：
BRAAK, H;BRAAK, E
异皮质内嗅区不会逐渐转变为颞叶同皮质。相反，有一个延伸的“transentorhinal”皮质与交错的异皮质和等皮质层。该过渡区的主要特征是大的多极神经细胞（Pre-α）的表层内嗅区的边缘逐渐向下扫过，并沿着倾斜的路线穿过外层。在此过程中，Pre-α的星形神经细胞转化为锥体细胞。层Pre-α.投射细胞特别容易发生阿尔茨海默型神经系统的变化。在早老性和老年性痴呆的情况下，几乎所有的Pre-α层投射神经元发生病理性改变。第二层至第四层的同皮质锥体细胞不太倾向于发生神经元性变化。在经内嗅皮层中，带有缠结的神经元沿着倾斜的路线穿过浅层，并最终位于等皮质层III和IV之间，这些发现证实了这些神经元是异皮质层Pre-α的组成部分的假设。深层的层特异性病理学也证实了经内嗅区是由交错的同种皮质层和同种皮质层形成的。
The allocortical entorhinal region does not gradually transform into the temporal isocortex. Instead, there is an extended stretch of "transentorhinal" cortex with interdigitation of allocortical and isocortical laminae. The main feature of this transition zone is that the superficial layer of large multipolar nerve cells (Pre-.alpha.) of the entorhinal region gradually sweeps downward and follows an oblique course through the outer layers. During this course the star-shaped nerve cells of Pre-.alpha. are transformed into pyramidal cells. The layer Pre-.alpha. projection cells are particularly prone to the development of neurofibrillary changes of the Alzheimer type. In cases of presenile and senile dementia almost all of the layer Pre-.alpha. projection neurons are changed pathologically. The isocortical pyramidal cells of layers II to IV are far less inclined to develop neurofibrillary changes. In the transentorhinal cortex, the tangle-bearing neurons follow an oblique course through the superficial laminae and are finally located between the isocortical layers III and IV, findings that confirm the assumption that these neurons are constituents of the allocortical layer Pre-.alpha.. Layer-specific pathology of the profound stratum as well confirms that transentorhinal region as being formed by interdigitating allocortical and isocortical layers.