Concentrations of selected heavy metals in placental tissues and risk for neonatal orofacial clefts
Concentrations of selected heavy metals in placental tissues and risk for neonatal orofacial clefts
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DOI：
10.1016/j.envpol.2018.07.112
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发表时间：
2018-11-01
影响因子：
8.9
通讯作者：
Ren, Aiguo
中科院分区：
文献类型：
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作者：
Pi, Xin;Qiao, Yiran;Ren, Aiguo
口面部裂(OFCs)的病因是多因素的。出生前接触重金属可以在动物模型中诱发OFCs，但来自人类受试者的研究证据很少。我们检查了胎盘组织中汞(Hg)、镉(Cd)、铅(Pb)和砷(As)的浓度是否与子代发生OFCS的风险有关。这项以人群为基础的病例对照研究从中国北部5个县的509名有胎盘样本的非畸形新生儿中随机抽取103名有胎盘组织的非畸形新生儿和206名对照。社会人口统计信息是通过面对面访谈中的结构化问卷收集的。用氦模式电感耦合等离子体质谱分析胎盘组织中汞、镉、铅和砷的浓度。OFC组汞(7.4 ng/g)、镉(57.1 ng/g)和铅(96.1 ng/g)中位数均显著高于对照组(分别为5.5 ng/g、38.6 ng/g和67.9 ng/g)，两组间As中位数差异无统计学意义。所有受试者的血药浓度高于中位数与患Cd的风险增加2.33倍(95%可信区间[CI]133-2.09)，患铅的风险增加3.08倍(95%可信区间1.74-5.47)。随着浓度的增加，发生OFCS的风险增加，调整后的优势比为3.06(95%CI 136~6.88)和8.18(95%CI 6.64~18.37)，3.88(95%CI 1.78~8.42)和5.17(95%CI 2.37~11.29)。在调整混杂因素后，汞浓度和OFC风险之间的关联几乎不显著。胎盘组织中镉和铅的浓度反映了产前对镉和铅的暴露，与新生儿糖化血红蛋白的风险增加有关。(C)2018爱思唯尔有限公司。保留所有权利。
Orofacial clefts (OFCs) have multifactorial etiologies. Prenatal exposure to heavy metals can induce OFCs in animal models, but evidence from studies of human subjects is scarce. We examined whether concentrations of mercury (Hg), cadmium (Cd), lead (Pb), and arsenic (As) in placental tissues are associated with risk for OFCs in offspring. This population-based case-control study included 103 newborns affected by OFCs with available placental tissues and 206 controls randomly selected from 509 non-malformed newborns with available placenta samples, recruited in five rural counties in northern China. Sociodemographic information was collected using a structured questionnaire in face-to-face interviews. The concentrations of Hg, Cd, Pb, and As in placental tissues were analyzed using an inductively coupled plasma-mass spectrometry in helium mode. The median concentrations of Hg (7.4 ng/g), Cd (57.1 ng/g), and Pb (96.1 ng/g) were all statistically significantly higher in OFC cases than in controls (Hg 5.5 ng/g, Cd 38.6 ng/g, and Pb 67.9 ng/g, respectively); no differences were observed between the two groups in median concentrations of As. Concentrations above the median for all subjects were associated with a 2.33-fold (95% confidence interval [CI] 133-2.09) increased OFC risk for Cd and a 3.08-fold (95% CI 1.74 -5.47) increased risk for Pb. The risk for OFCs increased with concentration tertiles, with an adjusted odds ratio of 3.06 (95% CI 136-6.88) for the second tertile and 8.18 (95% CI 6.64-18.37) for the highest tertile of Cd, and 3.88 (95% CI 1.78-8.42) for the second tertile and 5.17 (95% CI 2.37-11.29) for the highest tertile of Pb. The association between Hg concentration and OFC risk was borderline nonsignificant after adjusting for confounding factors. Prenatal exposure to Cd and Pb, as reflected by their concentrations in placental tissues, is associated with an increased risk for neonatal OFCs. (C) 2018 Elsevier Ltd. All rights reserved.