Comprehensive analysis of genetic polymorphisms in the interleukin-10 promoter: implications for immune regulation in specific ethnic populations.
Comprehensive analysis of genetic polymorphisms in the interleukin-10 promoter: implications for immune regulation in specific ethnic populations.
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白细胞介素 10 启动子遗传多态性的综合分析：对特定种族人群免疫调节的影响。
DOI：
10.1089/gte.2004.8.194
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Hughes,ThomasK
中科院分区：
文献类型：
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作者：
Rady,PeterL;Matalon,Reuben;Grady,James;Smith,EricM;Hudnall,SDavid;Kellner,LeonardH;Nitowsky,Harold;Tyring,StephenK;Hughes,ThomasK
白细胞介素-10 （IL-10）启动子单核苷酸多态性（snp）作为某些炎症性疾病、病毒感染、癌症和移植排斥反应的危险因素的关联已成为最近研究的主题。snp -1082 G→A， -819 C→T和-592 C→A与IL-10的差异产生有关，与种族密切相关。在这项研究中，我们确定了IL-10启动子snp的种族分布及其单倍型率在西班牙裔、非洲裔美国人和来自德克萨斯州的高加索人和来自纽约的德系犹太人中。发现IL-10 snp的患病率（及其单倍型分布）存在显著差异。与高加索人或德系犹太人相比，非裔美国人和西班牙裔美国人具有较低的推定高生产者snp，而具有较高的推定低IL-10生产者比率。在白种人和德系犹太人之间，等位基因频率和单倍型率没有统计学上的显著差异。该研究提供了IL-10启动子snp在美国地区人群中的种族分布的重要新信息，并且首次分析了未研究的德系犹太人的snp率。IL-10启动子多态性的知识可能在预测免疫应答、疾病严重程度和定制免疫治疗的智能设计中被证明是有用的。
The association of interleukin-10 (IL-10) promoter single-nucleotide polymorphisms (SNPs) as risk factors for certain inflammatory diseases, viral infections, cancers, and transplant rejection have been the subject of recent studies. The SNPs -1082 G → A, -819 C → T, and -592 C → A, which have been associated with differential IL-10 production, are strongly linked with ethnicity. In this study, we determined the ethnic distribution of IL-10 promoter SNPs and their haplotype rates among Hispanics, African Americans, and Caucasians from Texas and Ashkenazi Jews from New York. Significant differences in prevalence rates of IL-10 SNPs (and their haplotype distribution) were found. African Americans and Hispanics have a lower rate of putative high-producer SNPs and a higher rate of low IL-10 producers when compared to Caucasians or Ashkenazi Jews. No statistically significant differences in allelic frequencies and haplotype rates were observed between Caucasians and Ashkenazi Jews. This study provides critical new information on the ethnic distribution of IL-10 promoter SNPs in a regional U.S. population and is the first to analyze the rate of SNPs in an unstudied ethnic population, Ashkenazi Jews. Knowledge of IL-10 promoter polymorphisms may prove useful in prediction of immunization responses, disease severity, and in the intelligent design of customized immunotherapy.