ADP-ribosylation: from molecular mechanisms to human disease
ADP-ribosylation: from molecular mechanisms to human disease
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DOI：
10.1590/1678-4685-gmb-2019-0075
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发表时间：
2020-01-01
影响因子：
2.1
通讯作者：
Polo, Luis M.
中科院分区：
文献类型：
--
作者：
Hoch, Nicolas C.;Polo, Luis M.
以NAD（+）为底物的聚（ADP-核糖）聚合酶（PARP）催化的ADP-核糖基化对蛋白质的翻译后修饰在DNA损伤信号传导和修复中起核心作用，调节一系列细胞信号传导级联并通过parthanatos启动程序性细胞死亡。在这里，我们提出了ADP-核糖修饰，PARP激活和ADP-核糖信号传导的细胞功能的机制方面，并讨论了这些知识是如何揭示治疗日益普遍的人类疾病，如癌症，缺血性损伤和神经退行性疾病的治疗途径。
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD(+) as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.