One-pot synthesis of tetrasubstited pyrazoles - Proof of regiochemistry
One-pot synthesis of tetrasubstited pyrazoles - Proof of regiochemistry
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DOI：
10.1039/p19960001545
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发表时间：
1996-07-07
期刊：
影响因子：
--
通讯作者：
Williams, DJ
中科院分区：
文献类型：
--
作者：
Hanefeld, U;Rees, CW;Williams, DJ
以酰氯、丙二腈和烷基肼为原料，采用一锅三步法合成了稠杂环化合物中间体1-烷基-5-氨基-3-芳基-4-氰基吡唑。
1-Alkyl-5-amino-3-aryl-4-cyanopyrazoles, useful intermediates for fused heterocyclic systems, are synthesised by a one-pot three-step procedure from acid chlorides, malononitrile and alkylhydrazines, The regiochemistry of the hydrazine incorporation was proved in each case by X-ray crystallography and NMR spectroscopy.