Further evidence that stress hyperthermia is a fever.
Further evidence that stress hyperthermia is a fever.
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进一步证据表明应激性高热是发烧。
DOI：
10.1016/0031-9384(87)90263-0
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发表时间：
1987
影响因子：
2.9
通讯作者：
Vander,AJ
中科院分区：
文献类型：
--
作者：
Kluger,MJ;O'Reilly,B;Shope,TR;Vander,AJ
把老鼠暴露在野外会使体温迅速上升。54%的体温升高是通过脑室内使用解热药物水杨酸钠阻断的。腹腔注射吲哚美辛（一种有效的前列腺素阻滞剂）也能在相同程度上减轻应激性高热。根据本研究和早期研究的数据，我们得出结论，大鼠心理应激引起的体温升高的主要成分是由中枢神经系统释放的前列腺素介导的，因此可能是发烧。
Exposure of rats to an open-field results in a rapid rise in body temperature. Fifty-four percent of this rise in body temperature was blocked by intracerebroventricular administration of the antipyretic drug sodium salicylate. Intraperitoneal administration of indomethacin, a potent blocker of prostaglandin production, also attenuated the stress-induced hyperthermia to the same degree. Based on the data presented in this and an earlier study, we conclude that a major component of the rise in body temperature induced by psychological stress in rats is mediated by prostaglandins released by the central nervous system, and may therefore be a fever.