A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles
A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles
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DOI：
10.1021/acs.jpcc.5b02555
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发表时间：
2015-07-09
影响因子：
3.7
通讯作者：
Serantes, David
中科院分区：
文献类型：
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作者：
Conde-Leboran, Ivan;Baldomir, Daniel;Serantes, David
用于局部热疗癌症治疗的纳米级磁体的设计进展很大程度上是由试错方法推动的，例如，通过改变磁性实体的化学计量组成、大小和形状。到目前为止，已经报道了广泛不同且经常相互矛盾的散热结果，特别是作为纳米颗粒浓度的函数。因此，实现高温高效磁铁磁流体仍然是一个突出的挑战。在这里，我们证明了文献中发现的分散的散热模式实际上可以用一个单一的图像来描述粒子的固有磁性特征（各向异性，磁化）和实验条件（浓度，磁场）。重要的是，这种一般的磁热疗场景也预测了一种新的非单调浓度依赖，具有最佳的加热特征，我们通过微调颗粒大小在氧化铁纳米颗粒铁磁流体中实验证实了这一点。总的来说，我们的方法暗示了磁热疗的三难困境，这可能构成了开发磁性纳米材料以获得最佳热疗效率的简单策略。
Progress in the design of nanoscale magnets for localized hyperthermia cancer therapy has been largely driven by trial-and-error approaches, for instance, by changing of the stoichiometry composition, size, and shape of the magnetic entities. So far, widely different and often conflicting heat dissipation results have been reported, particularly as a function of the nanopartide concentration. Thus, achieving hyperthermia-efficient magnetic ferrofluids remains an outstanding challenge. Here we demonstrate that diverging heat-dissipation patterns found in the literature can be actually described by a single picture accounting for both the intrinsic magnetic features of the particles (anisotropy, magnetization) and experimental conditions (concentration, magnetic field). Importantly, this general magnetic-hyperthermia scenario also predicts a novel non-monotonic concentration dependence with optimum heating features, which we experimentally confirmed in iron oxide nanoparticle ferrofluids by fine-tuning the particle size. Overall, our approach implies a magnetic hyperthermia trilemma that may constitute a simple strategy for development of magnetic nanomaterials for optimal hyperthermia efficiency.