Toxicity of trimethylselenonium chloride in the rat with and without arsenite.
Toxicity of trimethylselenonium chloride in the rat with and without arsenite.
复制标题
含有和不含亚砷酸盐的三甲基氯化硒对大鼠的毒性。
DOI：
10.1016/0041-008x(71)90040-8
复制
发表时间：
1971
影响因子：
3.8
通讯作者：
A. Halverson
中科院分区：
文献类型：
--
作者：
B. Obermeyer;I. Palmer;O. Olson;A. Halverson
在大鼠中对氯化三甲基硒（TMSeCl）进行毒理学评价。ip LD_（50）为49.4mg Se/kg。在以亚砷酸盐形式注射4 mg/kg As的情况下，LD_（50）降低至2-3 mg/kg Se。三甲基碘化硫鎓的毒性与TMSeCl相似，但亚砷酸盐没有影响。为了进一步检查亚砷酸盐和TMSeCl之间的明显协同作用，研究了砷对呼吸和尿液中TMSe-硒消除的影响。在不同水平的硒管理，3-9%呼出，这一数额增加了亚砷酸盐注射。另一方面，亚砷酸盐注射液减少尿硒排泄。还发现，亚砷酸盐和二甲基硒（DMSe）的组合比单独注射时毒性更大，但亚砷酸盐并不影响从DMSe的硒呼气。当喂食TMSeCl时，需要高于240 ppm的硒水平来降低生长，即使在960 ppm的硒水平下，在5周的实验期内也没有观察到死亡。饮食中存在亚砷酸盐略微增加了在中等硒水平下饮食中施用的TMSeCl的毒性。
Trimethylselenonium chloride (TMSeCl) was submitted to a toxicologic evaluation in rats. The ip LD50 was 49.4 mg Se/kg. In the presence of 4 mg of As/kg injected as arsenite, the LD50 was reduced to 2–3 mg Se/kg. The toxicity of trimethylsulfonium iodide was similar to that for TMSeCl, but arsenite had no effect. To further examine the apparent synergism between arsenite and TMSeCl, the effect of arsenic on the elimination of TMSe-selenium in the breath and in the urine was studied. At different levels of selenium administration, 3–9% was exhaled, and this amount was increased by the injection of arsenite. On the other hand, arsenite injection reduced urinary selenium excretion. It was also found that arsenite and dimethyl selenide (DMSe) were more toxic in combination than when injected individually, but arsenite did not affect the exhalation of Se from DMSe. When TMSeCl was fed, levels above 240 ppm Se were required to reduce growth, and even at a level of 960 ppm Se, no deaths were observed in a 5-wk experimental period. The presence of arsenite in the diet slightly increased the toxicity of the TMSeCl administered in the diet at intermediate levels of selenium.