Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks.
Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks.
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DOI：
10.1021/acs.orglett.5b00329
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发表时间：
2015-04-03
期刊：
影响因子：
5.2
通讯作者：
Schroeder FC
中科院分区：
文献类型：
--
作者：
Yim JJ;Bose N;Meyer JM;Sommer RJ;Schroeder FC
在线虫模式生物秀丽隐杆线虫和太平洋棱纹线虫中，一类新的天然产物基于初级代谢衍生的构建块的模块化组装来控制生物体的发育和行为。我们报告的第一个五模代谢产物，pasa#9，和8-氧代腺嘌呤含npar#3从太平洋对虾的鉴定和生物活性。这些结构表明核苷和色氨酸代谢途径的协同选择，用于超越“初级”和“次级”代谢之间的二分法的内源性代谢物库的生物合成。
In the nematode model organisms Caenorhabditis elegans and Pristionchus pacificus, a new class of natural products based on modular assembly of primary-metabolism-derived building blocks control organismal development and behavior. We report identification and biological activities of the first pentamodular metabolite, pasa#9, and the 8-oxoadenine-containing npar#3 from P. pacificus. These structures suggest co-option of nucleoside and tryptophan metabolic pathways for the biosynthesis of endogenous metabolite libraries that transcend the dichotomy between “primary” and “secondary” metabolism.