Trends in the demographic and clinicopathological characteristics in Japanese patients with endometrial cancer, 1990-2010
Trends in the demographic and clinicopathological characteristics in Japanese patients with endometrial cancer, 1990-2010
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DOI：
10.2147/ijwh.s31541
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发表时间：
2012-01-01
影响因子：
2.3
通讯作者：
Hachisuga, Toru
中科院分区：
文献类型：
--
作者：
Honda, Taisei;Urabe, Rie;Hachisuga, Toru
目的：在过去的20年里，子宫内膜癌的发病率在日本显著增加。在日本人口中，老年女性的人数也有所增加。我们研究了高龄对日本子宫内膜癌患者的人口统计学和临床病理学特征的影响。方法：数据收集自1990年至2010年日本北九州市矢端西区职业与环境卫生大学医院的319例手术治疗的日本女性子宫内膜癌患者。进行了2次检验，以评估20年（A：1990- 2000年的116例）和（B：2001-2010年的203例）之间变量的趋势。还根据p53、雌激素受体和Ki-67的免疫组化表达来评估组织学亚型。结果：十年A组和十年B组的平均年龄+/-标准差分别为57.5岁+/- 9.7岁和61.0岁+/- 11.3岁（P < 0.02）。70岁或以上的患者比例以及高风险组织学肿瘤包括浆液性癌、透明细胞癌和癌肉瘤的比例增加（十年A组和十年B组：9.5%vs27.6%，P < 0.001，10.4%vs21.6%，P = 0.01），而晚期手术（III和IV），肥胖（体重指数>= 25），未产率10年A组和10年B组分别为23.3%vs29.1%，P = 0.30，28.4%vs33.0%，P = 0.40，分别为19.0%和21.2%，P = 0.66。十年A组和十年B组的癌症特异性生存率分别为78.6%和77.6%（P = 0.93）。结论：日本人口中老年女性数量的增加与高危子宫内膜癌的增加有关。需要进行一项研究，以探讨预防策略，并改善老年高危子宫内膜癌患者的治疗。
Objective: Over the past 20 years, the incidence of endometrial cancer has increased remarkably in Japan. The number of elderly females has also increased within the population of Japan. We examined the impact of advanced age on the demographic and clinicopathological characteristics in Japanese patients with endometrial cancer.Methods: Data were collected from 319 surgically treated Japanese females with endometrial cancer from the files of the University Hospital of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan, between 1990 and 2010..2 tests were performed to evaluate the trends in the variables between two decades (A: 116 cases from 1990- 2000) and (B: 203 cases in 2001-2010). The histological subtypes were also evaluated based on the immunohistochemical expressions of p53, estrogen receptor, and Ki-67.Results: The mean ages +/- standard deviation in the decade A group and the decade B group were 57.5 years +/- 9.7 years and 61.0 years +/- 11.3 years, respectively (P < 0.02). There was an increase in the proportion of patients aged 70 years or older and of high-risk histological tumors including serous carcinoma, clear cell carcinoma, and carcinosarcoma (decade A group and decade B group: 9.5% vs 27.6%, P < 0.001, 10.4% vs 21.6%, P = 0.01, respectively), while the advanced surgical stage (III and IV), obesity (>= 25 of body mass index), and nulliparity of the decade A group and decade B group were 23.3% vs 29.1%, P = 0.30, 28.4% vs 33.0%, P = 0.40, and 19.0% vs 21.2%, P = 0.66, respectively. The cancer-specific survival rates in the decade A group and the decade B group were 78.6% and 77.6%, respectively (P = 0.93).Conclusion: The increase in number of elderly females in the Japanese population is related to the increase in that of high-risk endometrial cancers. A study is needed to investigate prevention strategies and to improve the treatment of elderly patients with high-risk endometrial cancer.