Viral potentiation of bacterial superinfection of the respiratory tract
Viral potentiation of bacterial superinfection of the respiratory tract
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DOI：
10.1016/s0966-842x(00)88892-7
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发表时间：
1995-01-01
影响因子：
15.9
通讯作者：
Bakaletz, Lauren O.
中科院分区：
文献类型：
--
作者：
Bakaletz, Lauren O.
呼吸道的病毒感染使其易受细菌重叠感染。流行病学研究、病毒-细菌共感染的临床证据和这种相互作用的动物模型表明了事件的时间过程和可能发生病毒增强的几种机制。呼吸道粘膜上皮的结构和功能破坏似乎是双重感染协同效应的主要贡献者。
Virus infections of the respiratory tract predispose it to bacterial superinfections. Epidemiological studies, clinical evidence of viral-bacterial co-infection and animal models of such interactions suggest a time course of events and several mechanisms by which viral potentiation may occur. It appears that structural and functional disruption of the respiratory mucosal epithelium is a major contributor to the synergistic effects of superinfection.