Maternal telomere length is shorter in intrauterine growth restriction versus uncomplicated pregnancies, but not in the offspring or in IVF-conceived newborns
Maternal telomere length is shorter in intrauterine growth restriction versus uncomplicated pregnancies, but not in the offspring or in IVF-conceived newborns
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DOI：
10.1016/j.rbmo.2018.12.008
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发表时间：
2019-04-01
影响因子：
4
通讯作者：
Blasco, Maria A.
中科院分区：
文献类型：
--
作者：
Perales-Puchalt, Alfredo;Soberon, Nora;Blasco, Maria A.
研究问题：这项研究的目的是确定是否试管婴儿或宫内生长受限（IUGR）的结果在短的新生儿端粒，这可以解释在这些population.Design描述的心血管和代谢疾病的风险较高：这是一个观察，分析，横断面，前瞻性研究与控制在三级医院。主要结果是测定126名新生儿及其母亲（n = 109）的白细胞端粒长度。新生儿自然受孕或通过IVF受孕，并对无并发症和IUGR妊娠进行了研究。结果：体外受精（IVF）或IUGR新生儿与自然受孕的健康新生儿的端粒平均长度差异无统计学意义（分别为P = 0.466和P = 0.732）;在控制混杂因素（分别为P = 0.218和P = 0.991）后仍然如此。IUGR组母亲的平均端粒长度较正常妊娠组母亲短（P = 0.023），控制年龄、体重指数和吸烟习惯后，差异有统计学意义（P = 0.034）。IUGR母亲较短的端粒可能代表较高的心血管风险，这将在其他健康成年人的妊娠压力下具有临床意义。
Research question: The study aimed to determine whether IVF or intrauterine growth restriction (IUGR) result in short neonatal telomeres, which could explain the higher risk of cardiovascular and metabolic disease described in these populations.Design: This was an observational, analytical, cross-sectional, prospective study with controls in a tertiary hospital. The main outcome was to determine the leukocyte telomere length in 126 newborns and their mothers (n = 109). Newborns were conceived spontaneously or by IVF, and uncomplicated and IUGR pregnancies were studied. Telomere lengths were measured using high-throughput telomere quantitative fluorescent in-situ hybridization.Results: There was no difference in average telomere length between newborns conceived by IVF or those with IUGR and spontaneously conceived healthy newborns (P = 0.466 and P = 0.732, respectively); this remained after controlling for confounders (P = 0.218 and P = 0.991, respectively). Mothers of newborns with IUGR had a shorter average telomere length than women with uncomplicated pregnancies (P = 0.023), which was confirmed after controlling for age, body mass index and smoking habit (P = 0.034).Conclusions: The results support the safety of IVF and IUGR in terms of the postnatal health of the newborns. The shorter telomeres of IUGR mothers may represent a higher cardiovascular risk, which would have clinical implications under the stress of pregnancy in otherwise healthy adults.