Current Concepts in Chemotherapy for Head and Neck Cancer
Current Concepts in Chemotherapy for Head and Neck Cancer
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DOI：
10.1016/j.coms.2018.09.003
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发表时间：
2019-02-01
影响因子：
1.5
通讯作者：
Bauman, Julie E.
中科院分区：
文献类型：
--
作者：
Sindhu, Simran K.;Bauman, Julie E.
本文重点介绍了支持头颈部鳞状细胞癌(HNSCC)患者系统治疗选择的循证数据。人乳头状瘤病毒在HNSCC中的流行及其良好的预后已成为研究的主要焦点。患者被分成临床或病理风险类别，并参加试验，比较标准治疗模式与去强化治疗模式、低风险疾病治疗模式或强化治疗模式、中等风险疾病或高风险疾病治疗模式。免疫疗法已被证明在二线姑息疗法中是有益的，目前正在研究一线姑息疗法，并将其作为高危患者明确的多模式治疗的组成部分。
This article highlights the evidence-based data to support systemic treatment options for patients with head and neck squamous cell carcinoma (HNSCC). The discovery of the human papillomavirus epidemic in HNSCC and its favorable prognosis has led to a major focus of research. Patients are stratified into clinical or pathologic risk categories and enrolled in trials comparing standard treatment paradigms with deintensification, in low-risk disease, or to intensification, in intermediate-risk or high-risk disease. Immunotherapy has proven beneficial in second-line palliative therapy and is under investigation in first-line palliative therapy and as a component of definitive, multimodality therapy for high-risk patients.