Two-stage dispersion polymerization toward monodisperse, controlled micrometer-sized copolymer particles
Two-stage dispersion polymerization toward monodisperse, controlled micrometer-sized copolymer particles
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DOI：
10.1021/ja048862d
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发表时间：
2004-06-02
影响因子：
15
通讯作者：
Winnik, MA
中科院分区：
文献类型：
--
作者：
Song, JS;Tronc, F;Winnik, MA
我们描述了一个两阶段的分散聚合过程，以制备单分散的微米级聚合物颗粒，其中有问题的试剂，如功能单体和交联剂，通常破坏的颗粒形成过程中，加入到反应后的成核阶段完成。在该点之后加入的共聚单体被结合到颗粒中，而不干扰最终的粒度和粒度分布。以这种方式，制备具有非常窄的尺寸分布的染料标记的或含有官能团的微米尺寸的颗粒。通过改变在第二阶段中加入的单体的量，可以精确地控制最终粒径。最重要的是，这种合成策略使我们能够制备含有高达3摩尔%交联剂的交联颗粒。
We describe a two-stage dispersion polymerization process to prepare monodisperse micrometer-sized polymer particles in which problematic reagents, such as functional monomers and cross-linkers that commonly disrupt the particle-forming process, were added to the reaction after the nucleation stage was complete. Comonomers added after this point became incorporated into the particles without disturbing the final particle size and size distribution. In this way dye-labeled or functional group-containing micrometer-sized particles with a very narrow size distribution were prepared. By varying the amount of monomer added in the second stage, the final particle diameter could be controlled precisely. Most important of all, this synthetic strategy allowed us to prepare cross-linked particles containing up to 3 mol % cross-linking agent.