Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia
Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia
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DOI：
10.1016/s0002-9149(01)02264-0
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发表时间：
2002-02-15
影响因子：
2.8
通讯作者：
Tracy, RP
中科院分区：
文献类型：
--
作者：
Kop, WJ;Gottdiener, JS;Tracy, RP
抑郁症与心血管疾病的增加有关，但其潜在的机制尚不清楚。这项研究调查了65岁老人抑郁症状与炎症和凝血因子的关系。血液样本来自4,268名无心血管疾病的受试者(年龄72.4+/-5.5岁，2623名女性)。炎症标志物包括C反应蛋白(CRP)、白细胞计数(WBC)、血小板总数和白蛋白；凝血因子包括VIIC、VIIIc和纤维蛋白原。抑郁用流行病学研究中心抑郁量表进行评估，能量耗竭状态用有效的耗竭指数进行评估。对危险因素(年龄、性别、种族、收缩压、吸烟状况、糖尿病)和身体虚弱程度(等长握力、计时15英尺步行测试、活动水平)进行了统计调整。抑郁与C反应蛋白(3.31+/-0.10vs3.51+0.21 mg/L)、白细胞(6.14+/-0.03vs6.43+/-0.11(6)/L)、纤维蛋白原(319+/-1vs326+/-3 mg/dl)、VIIC(124.6+/-0.6%vs127.2+/-1.3%)相关；
Depression is associated with increased cardiovascular disease, but the underlying mechanisms are not well understood. This study examines associations of depressive symptoms with inflammation and coagulation factors in persons aged >65 years. Blood samples were obtained from 4,268 subjects free of cardiovascular disease (age 72.4 +/- 5.5 years, 2,623 women). Inflammation markers were C-reactive protein (CRP), white blood cell (WBC) count, total platelet count, and albumin; coagulation factors included factors VIIc and VIIIc and fibrinogen. Depression was assessed with the Center for Epidemiologic Studies Depression scale, and states of energy depletion with a validated exhaustion index. Statistical adjustments were made for risk factors (age, sex, race, systolic blood pressure, smoking status, diabetes mellitus) and physical measures of frailty (isometric handgrip, timed 15-feet walk test, activity level). Depression was associated with elevated CRP (3.31 +/- 0.10 vs 3.51 +/- 0.21 mg/L), WBC (6.14 +/- 0.03 vs 6.43 +/- 0.11 10(6)/L), fibrinogen (319 +/- 1 vs 326 +/- 3 mg/dl), and factor VIIc (124.6 +/- 0.6% vs 127.2 +/- 1.3%; all p