The New York Cancer Project: Rationale, organization, design, and baseline characteristics
The New York Cancer Project: Rationale, organization, design, and baseline characteristics
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DOI：
10.1093/jurban/jth116
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发表时间：
2004-06-01
影响因子：
6.6
通讯作者：
Vlahov, D
中科院分区：
文献类型：
--
作者：
Mitchell, MK;Gregersen, PK;Vlahov, D
癌症是纽约市的第二大死因，每年有近15,000人死亡。纽约市的城市环境为大量和多样化的人群提供了便利的途径，可以检查这些人群在癌症风险和预后方面的种族/民族差异。开展了一项新的队列研究，目的有几个：(1)为癌症病因和发病机制的研究提供数据库和生物信息库，包括宿主遗传学；(2)区分导致癌症风险、预防、控制、发病率、死亡率和存活率存在种族/民族差异的风险因素；(3)提供可用于动员和评估公共卫生项目的癌症风险和预防行为的及时数据。来自多个机构的科学家参与了协议的设计和实施。研究工具包括人口统计学、癌症个人和家族史、风险和预防努力。终点包括与登记处和病历审查的联系。使用基于场地的配额抽样，在一年多的时间里招募了18,187名年龄在30岁或以上的成年人接受基线问卷调查、静脉穿刺术和联系方式。样本中39%是男性，37%是50岁以上，58%是白人，20%是非裔美国人，18%是西班牙裔，9%是亚洲人。在癌症家族史方面，21%的人报告了母亲，21%的人报告了父亲，5.9%的人报告了父母双方都患有癌症；8.5%的人报告了兄弟姐妹患有癌症。在基线时，1231名参与者报告患有癌症。为了显示在纽约市建立一个队列的可行性，计划继续进行更多的招募和对关于癌症的突出问题的分析。
Cancer is the second leading cause of death in New York City, with nearly 15,000 deaths each year. The urban setting of New York City provides ready access to large and diverse populations for whom racial/ethnic disparities in cancer risk and outcomes can be examined. A new cohort study was undertaken with several aims: (1) to provide a database and biorepository for studies of cancer etiology and pathogenesis, including host genetics; (2) to differentiate risk factors that contribute to racial/ethnic disparities in cancer risk, prevention, control, incidence, mortality, and survival; (3) to provide timely data on cancer risk and preventive behaviors that can be used to mobilize and then evaluate public health programs. Scientists from multiple institutions contributed to protocol design and implementation. Study instruments included demographics, personal and family history of cancer, risk and prevention efforts. End points include linkage with registries and medical record reviews. Using venue-based sampling with quotas, 18,187 adults aged 30 years or older were recruited over a year to undergo a baseline questionnaire, venipuncture, and contact information. The sample was 39% male, 37% older than 50 years, 58% white, 20% African American, 18% Hispanic, and 9% Asian. In terms of family history of cancer, 21% reported mother, 21 reported father, and 5.9% reported both parents with cancer; 8.5% reported any sibling with cancer. At baseline, 1,231 participants reported prior cancer. Showing the feasibility of constructing a cohort based in New York City, plans proceed for additional recruitment and analyses on the salient questions about cancer.