Body fatness and physical activity at young ages and the risk of breast cancer in premenopausal women
Body fatness and physical activity at young ages and the risk of breast cancer in premenopausal women
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DOI：
10.1038/sj.bjc.6602758
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发表时间：
2005-10-03
影响因子：
8.8
通讯作者：
Beral, V
中科院分区：
文献类型：
--
作者：
Magnusson, CMK;Roddam, AW;Beral, V
我们从英国三项相关的基于人群的病例对照研究中，对1560例绝经前病例和1548例对照进行了身体肥胖、运动参与和乳腺癌风险之间的关系进行了研究。一半患有乳腺癌的女性在确诊时年龄不到36岁。在10岁时认为自己胖的女性与认为自己瘦的女性相比，相对风险为0.83(95%可信区间0.69-0.99，P=0.03)。自我报告的肥胖与确诊时的消瘦相比，相对危险度为0.78(95%可信区间为0.56-1.06，P=0.11)。报告10岁时肥胖和确诊时超重或肥胖的女性与那些10岁时报告瘦的女性相比，相对风险为0.75(95%可信区间0.56-1.01，P=0.06)。对身体肥胖的三项相关测量结果表明，肥胖与绝经前乳腺癌的风险降低有关。在这些绝经前女性中，运动参与与乳腺癌风险之间没有关联。每周平均运动时间超过1小时的相对危险度为1.00(95%CI为0.86~1.16，P=0.98)。
We examined the relationship between body fatness, sports participation and breast cancer risk in 1560 premenopausal cases and 1548 controls, from three related population-based case - control studies in the UK. Half of the women with breast cancer were aged less than 36 years at diagnosis. Women who perceived themselves as plump at age 10 years had a relative risk of 0.83 (95% confidence interval 0.69 - 0.99, P = 0.03) as compared with those who perceived themselves as thin. Self-reported obesity compared with leanness at diagnosis was associated with a relative risk of 0.78 ( 95% confidence interval 0.56 - 1.06, P = 0.11). Women who reported having been plump at age 10 years and overweight or obese at diagnosis had a relative risk of 0.75 ( 95% confidence interval 0.56 - 1.01, P = 0.06) as compared with those who reported being thin at age 10 years and at diagnosis. Findings for three related measures of body fatness suggested that obesity is associated with a reduced risk of premenopausal breast cancer. There was no association between sports participation and breast cancer risk in these premenopausal women. The relative risk for spending an average of more than 1 h per week in sports compared with less from ages 12 to 30 years was 1.00 ( 95% CI 0.86 - 1.16, P = 0.98).