Shigella "Osp"pression of innate immunity.
Shigella "Osp"pression of innate immunity.
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先天免疫的志贺氏菌“Osp”抑制。
DOI：
10.1016/j.cell.2022.05.027
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发表时间：
2022
期刊：
影响因子：
64.5
通讯作者：
Vanaja,SivapriyaKailasan
中科院分区：
文献类型：
--
作者：
Wright,SkylarS;Vanaja,SivapriyaKailasan
干扰素是有效的抗微生物效应物，因此是病原体干扰的有吸引力的靶标。在本期的《细胞》杂志中，Alphonse et al.揭示了志贺氏菌效应子OspC1和OspC3采用了一种令人惊讶的机制来阻断干扰素信号传导并减弱抗菌反应，从而确保其复制生态位。
Interferons are potent antimicrobial effectors and thus an attractive target for pathogen interference. In this issue ofCell, Alphonse et al. reveal that theShigellaeffectors OspC1 and OspC3 employ a surprising mechanism to block interferon signaling and attenuate antibacterial responses, thus securing their replicative niche.