Cerium ion promotes the osteoclastogenesis through the induction of reactive oxygen species
Cerium ion promotes the osteoclastogenesis through the induction of reactive oxygen species
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铈离子通过诱导活性氧促进破骨细胞生成
DOI：
10.1016/j.jtemb.2018.12.006
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发表时间：
--
影响因子：
3.5
通讯作者：
Yang Xiaochao
中科院分区：
文献类型：
--
作者：
Zhou Lan;Tang Shupei;Yang Lu;Huang Xiaoyong;Zou Ling;Huang Yu;Dong Shiwu;Zhou Xinyuan;Yang Xiaochao
近几十年来，含Ce和含Ce的材料在工业和生物医学领域的应用受到越来越多的关注。Ce应用的增加也增加了人体暴露于Ce离子的风险。由于其离子半径与钙(II)相似，Ce(III)主要沉积在骨骼系统中。然而，Ce(III)对骨代谢动态平衡的影响仍然知之甚少。在本研究中，研究了Ce(III)对破骨细胞生成的影响，破骨细胞在骨代谢动态平衡中起着关键作用。Ce(III)可促进NADPH氧化酶1(Nox1)的表达和活性，导致细胞内活性氧(ROS)水平升高。ROS水平的升高激活了RANKL依赖的破骨细胞分化途径，促进了破骨细胞的分化，而与Ce(III)离子结合的阴离子对破骨细胞的分化没有影响。Ce(III)激活的破骨细胞表现出增强的骨吸收能力。这些结果为了解Ce(III)对骨骼系统代谢动态平衡的潜在影响提供了基础信息，对Ce盐未来的生物医学应用具有重要的参考价值。
Cerium and cerium containing materials have been drawing increasing attentions in industrial and biomedical applications in recent decades. The increased applications of cerium have also increased the risk of human body exposed to cerium ions. Due to its similar ionic radius to calcium(II), cerium(III) have found mainly deposited in the skeletal system. However, the effects of cerium(III) on the bone metabolism homeostasis remain poorly understood. In the present study, the effect of cerium(III) on the osteoclastogenesis which plays a pivotal role in bone metabolism homeostasis was investigated. Cerium(III) could enhance the expression and activity of NADPH oxidase1 (Nox1) leading to the elevation of intracellular reactive oxygen species (ROS) level. The augmentation of ROS level activated the RANKL dependent osteoclasts differentiation pathways resulted in the promotion of osteoclastogenesis, while anions associated with cerium(III) cation have no effects on the differentiation of osteoclasts. The cerium(III) activated osteoclasts exhibited enhanced bone resorption capability. These results provided fundamental information for understanding the potential effects of cerium(III) on the metabolism homeostasis of skeletal system which is of great reference value for future biomedical applications of cerium salts.