Donor bone marrow infusions are tolerogenic in human renal transplantation
Donor bone marrow infusions are tolerogenic in human renal transplantation
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DOI：
10.1016/s0041-1345(00)02485-4
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发表时间：
2001-02-01
影响因子：
0.9
通讯作者：
Miller, J
中科院分区：
文献类型：
--
作者：
Ciancio, G;Garcia-Morales, R;Miller, J
63例DBMC患者中有3例发生慢性排斥反应（活检CR，血清肌酐升高> 2 mg/dL）。其中两人在肾移植活检中诊断出多瘤病毒。这与219例CAD对照组中42例具有相同的慢性排斥反应参数（P.01）形成对比。在DBMC组中，术后1 - 4年每年连续髂嵴骨髓穿刺中，通过定量PCR-ffow方法测量的嵌合体增加了3倍，CAD组中一些患者现在有3%的嵌合体DBMC。
RESULTSThere were 3 of 63 DBMC patients who had chronic rejection (CR on biopsy and increasing serum creatinines 2 mg/dL). Two of these had polyoma virus diagnosed in their kidney transplant biopsies. This was in contrast with 42 of the 219 CAD controls with the same chronic rejection parameters (P. 01). In the DBMC group, chimerism as measured by the quantitative PCR-ffow method has increased threefold in yearly sequential iliac crest bone marrow aspirations between 1 and 4 years postoperatively, with some patients now having 3% chimeric DBMC in the CAD group.