Post-Transcriptional Regulation of Noise in Protein Distributions during Gene Expression
Post-Transcriptional Regulation of Noise in Protein Distributions during Gene Expression
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DOI：
10.1103/physrevlett.105.018101
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发表时间：
2010-06-28
影响因子：
8.6
通讯作者：
Kulkarni, Rahul V.
中科院分区：
文献类型：
--
作者：
Jia, Tao;Kulkarni, Rahul V.
基因表达的内在随机性可能导致细胞群中蛋白质水平的巨大变化。蛋白质分布的变异性（或噪音）可以通过基因调控的细胞机制来调节；特别是，人们对理解转录后调控的作用非常感兴趣。为了解决这个问题，我们提出并分析了基因表达转录后调控的随机模型。该模型的解析解可深入了解转录后调节的不同机制对蛋白质分布噪声的影响。获得的结果还证明了如何根据受调节蛋白质分布的观察来区分基因表达中内在噪声的不同来源。
The intrinsic stochasticity of gene expression can lead to a large variability of protein levels across a population of cells. Variability (or noise) in protein distributions can be modulated by cellular mechanisms of gene regulation; in particular, there is considerable interest in understanding the role of post-transcriptional regulation. To address this issue, we propose and analyze a stochastic model for post-transcriptional regulation of gene expression. The analytical solution of the model provides insight into the effects of different mechanisms of post-transcriptional regulation on the noise in protein distributions. The results obtained also demonstrate how different sources of intrinsic noise in gene expression can be discriminated based on observations of regulated protein distributions.