Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis
Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis
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DOI：
10.1097/moo.0b013e32832ad23d
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发表时间：
2009-06-01
影响因子：
1.6
通讯作者：
Schlosser, Rodney J.
中科院分区：
文献类型：
--
作者：
Wise, Sarah K.;Ahn, Chadwick N.;Schlosser, Rodney J.
综述目的本文综述了免疫球蛋白E(IgE)在各种鼻腔炎症条件下的局部组织鉴定的最新文献。对变态反应性鼻炎和非变应性鼻炎、特应性和非特应性鼻息肉、变应性真菌性鼻窦炎的局部IgE表达进行了讨论。最近的发现全身过敏试验阴性的患者鼻灌洗液中IgE水平升高，过敏原激发试验阳性。此外，在鼻息肉患者中已发现交链孢属特异性IgE水平升高；这被认为是鼻息肉病发展的一个促成因素。进一步的证据支持局部IgE对金黄色葡萄球菌超抗原在特应性和非特应性鼻息肉病中的作用。在变态反应性和非变应性鼻炎、特应性和非特应性鼻息肉和变应性真菌性鼻窦炎患者的鼻窦组织中，已发现局部特异性IgE水平升高。在炎症性鼻窦疾病状态下识别局部组织IgE的能力可能具有重要的诊断和治疗意义。
Purpose of reviewThis article reviews recent literature on local tissue identification of immunoglobulin E (IgE) in various sinonasal inflammatory conditions. Discussions of local IgE expression in allergic and nonallergic rhinitis, atopic and nonatopic sinonasal polyposis, and allergic fungal rhinosinusitis are included.Recent findingsIncreased levels of IgE and positive reactivity on nasal allergen provocation tests have been demonstrated in nasal lavage fluid of patients with negative systemic allergy testing. In addition, elevated levels of Alternaria alternata-specific IgE have been identified in nasal polyp patients; this is hypothesized as a contributory factor in the development of nasal polyposis. Further evidence supports the role of local IgE to Staphylococcus aureus superantigens in atopic and nonatopic nasal polyposis. Finally, local IgE specific for a range of antigens has been identified in sinus and inferior turbinate tissue in patients with allergic fungal rhinosinusitis.SummaryIncreased levels of IgE have been identified in sinonasal tissues in allergic and nonallergic rhinitis, atopic and nonatopic sinonasal polyposis, and allergic fungal rhinosinusitis. The ability to identify local tissue IgE in inflammatory sinonasal disease states may have significant diagnostic and therapeutic implications.