Intratumoral administration of carboplatin for treatment of squamous cell carcinomas of the nasal plane in cats.
Intratumoral administration of carboplatin for treatment of squamous cell carcinomas of the nasal plane in cats.
复制标题
卡铂瘤内给药用于治疗猫鼻平面鳞状细胞癌。
DOI：
10.2460/ajvr.1996.57.02.205
复制
发表时间：
1996
影响因子：
1
通讯作者：
B. Madewell
中科院分区：
文献类型：
--
作者：
A. Théon;Melinda K. VanVechten;B. Madewell
目的
开发用于猫肿瘤内给药的缓释卡铂制剂。
设计
初步研究旨在分析瘤内给药卡铂制剂中纯化芝麻油的药代动力学效应，第二项研究旨在评价瘤内给药纯化芝麻油中卡铂的疗效和毒性。
动物
23只患鼻平面鳞状细胞癌的猫。
程序
采用两阶段交叉设计，对8只患有晚期肿瘤的猫进行了100 mg卡铂/m2体表面积的瘤内给药，含或不含纯化芝麻油。另外15只猫通过瘤内给予卡铂（溶于纯化芝麻油）进行治疗。以1.5 mg/cm 3组织的剂量给予卡铂的纯化芝麻油瘤内化疗注射，每周4次。
结果
制剂中的纯化芝麻油显著降低了卡铂的全身暴露和注射部位的药物渗漏。未观察到重复肿瘤内给药对卡铂血浆浓度的累积效应。未观察到全身中毒，局部中毒极轻微。溃疡性病变的愈合未受到影响。临床肿瘤完全清除率和完全缓解率分别为67%和73.3%。平均无进展生存时间的产品限值估计为16 +/- 3.3个月。1年无进展生存率为55.1 ± 13%。在7只猫中观察到局部复发; 4只有边缘肿瘤复发，3只有视野内和边缘肿瘤复发。
结论
瘤内卡铂化疗是安全和有效的猫与鳞状细胞癌的鼻平面。未来提高治疗效果的研究可能包括评估增加的剂量强度以及这种方式与放疗的结合。
临床相关性
卡铂水芝麻油乳剂瘤内给药被认为是猫面部鳞状细胞癌的一种实用有效的新治疗方法。
OBJECTIVE
To develop a slow-release carboplatin formulation for intratumoral administration to cats.
DESIGN
Preliminary study to analyze pharmacokinetic effects of purified sesame oil in the carboplatin formulation for intratumoral administration, and a second study to evaluate the efficacy and toxicosis of intratumoral administration of carboplatin in purified sesame oil.
ANIMALS
23 cats with squamous cell carcinomas of the nasal plane.
PROCEDURE
Eight cats with advanced-stage tumors were submitted to intratumoral administration of 100 mg of carboplatin/m2 of body surface area, with or without purified sesame oil, using a two-period, cross-over design. Fifteen additional cats were treated by intratumoral administration of carboplatin in purified sesame oil. Four weekly intratumoral chemotherapy injections of carboplatin in purified sesame oil at a dosage of 1.5 mg/cm3 of tissue were given.
RESULTS
Purified sesame oil in the formulation significantly reduced systemic exposure to carboplatin and drug leakage from the sites of injection. Cumulative effects of repeated intratumoral administrations on plasma concentrations of carboplatin were not observed. Systemic toxicosis was not observed, and local toxicosis was minimal. Healing of ulcerated lesions was not compromised. Rates of complete clinical tumor clearance and complete response were 67 and 73.3%, respectively. Product-limit estimates of mean progression-free survival times was 16 +/- 3.3 months. The 1-year progression-free survival rate was 55.1 +/- 13%. Local recurrence was observed in 7 cats; 4 had marginal tumor recurrence, and 3 had in-field and marginal tumor recurrence.
CONCLUSIONS
Intratumoral carboplatin chemotherapy is safe and effective for cats with squamous cell carcinoma of the nasal plane. Future studies to improve treatment efficacy could include evaluation of increased dose-intensity as well as combination of this modality with radiotherapy.
CLINICAL RELEVANCE
Intratumoral administration of carboplatin in a water-sesame-oil emulsion was found to be a practical and effective new treatment for facial squamous cell carcinomas in cats.