RELIABILITY OF THE MAXIMUM DERIVATIVES OF LEFT-VENTRICULAR PRESSURE AND INTERNAL DIAMETER AS INDEXES OF THE INOTROPIC STATE OF THE DEPRESSED MYOCARDIUM
RELIABILITY OF THE MAXIMUM DERIVATIVES OF LEFT-VENTRICULAR PRESSURE AND INTERNAL DIAMETER AS INDEXES OF THE INOTROPIC STATE OF THE DEPRESSED MYOCARDIUM
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DOI：
10.1093/cvr/13.11.652
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发表时间：
1979-01-01
影响因子：
10.8
通讯作者：
BISHOP, VS
中科院分区：
文献类型：
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作者：
BARNES, GE;HORWITZ, LD;BISHOP, VS
在8条狗上研究了正性肌力刺激和舒张末期内径、主动脉压、左室末端内径、平均动脉压和心率的增加对左室压力最大变化率（dP/dtmax）和左室内径最大变化率（dD/dtmax）的影响。反应进行了研究，在正常的意识状态下，在心肌抑制由于高剂量的戊巴比妥或普萘洛尔，和双侧心脏交感神经切除术后。在研究的所有状态下，两个dP/dtmax大幅增加变力性刺激异丙肾上腺素和舒张末期直径的变化，平均动脉压和心率的影响较小。这两个指数是高度敏感的左心室的收缩状态和相对不敏感的血流动力学改变在正常和抑郁的心脏。
The effects of inotropic stimulation and increases in end-diastolic diameter, aortic pressure, left ventricular end diameter size, mean arterial pressure, and heart rate on maximum rate of change of left ventricular pressure (dP/dtmax) and diameter (dD/dtmax) were studied in 8 dogs. Responses were studied in the normal conscious state, during myocardial depression due to high doses of pentobarbital or propranolol, and after bilateral cardiac sympathectomy. In all states studied, both dP/dtmax were substantially augmented by inotropic stimulation with isoprenaline and were less influenced by changes in end-diastolic diameter, mean arterial pressure and heart rate. Both indices are highly sensitive to the contractile state of the left ventricle and relatively insensitive to hemodynamic alterations in both normal and depressed hearts.