Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses
Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses
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DOI：
10.1038/11184
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发表时间：
1999-08-01
影响因子：
25
通讯作者：
Staley, KJ
中科院分区：
文献类型：
--
作者：
Bains, JS;Longacher, JM;Staley, KJ
在海马脑片中，同步CA3网络活动诱导持续加强积极的正反馈突触。这通过增加未来同步网络激活的概率来改变网络操作。在同步网络活动过程中，部分阻断NMDA受体引起的突触强度的长期抑制逆转了自发网络激活概率的变化。这些结果表明，特定的网络活动模式选择性地改变活动突触的强度。网络活动的稳定、可逆的改变也可以通过突触强度的相应改变来实现。这些发现证实了Hebb记忆模型在神经网络水平，并提出了新的治疗癫痫网络活动的病理模式。
In hippocampal slices, synchronous CA3 network activity induced persistent strengthening of active positive-feedback synapses. This altered network operation by increasing probability of future synchronous network activation. Long-term depression of synaptic strength induced by partial blockade of NMDA receptors during synchronous network activity reversed changes in probability of spontaneous network activation. These results suggest that specific network activity patterns selectively alter strength of active synapses. Stable, reversible alterations in network activity can also be effected by corresponding alterations in synaptic strength. These findings confirm the Hebb memory model at the neural-network level and suggest new therapies for pathological patterns of network activity in epilepsy.