Long lasting pure freezing of gait preceding progressive supranuclear palsy:: A clinicopathological study
Long lasting pure freezing of gait preceding progressive supranuclear palsy:: A clinicopathological study
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DOI：
10.1002/mds.21612
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发表时间：
2007-10-15
影响因子：
8.6
通讯作者：
Valls-Solé, Josep
中科院分区：
文献类型：
--
作者：
Compta, Yaroslau;Valideoriola, Francesc;Valls-Solé, Josep
原发性进行性步态冻结 (PPFG) 是一个术语，用于指代一种不常见的病症，其特征是步态冻结并经常跌倒，无运动迟缓、强直或震颤，并且对左旋多巴无反应。文献中关于PPFG患者的病理报告很少。我们报告了 2 名患者（其中一名经病理证实）最初被诊断为 PPFG，并在症状出现 10 多年后演变为临床定义的进行性核上性麻痹 (PSP)。这两个病例表明，PPFG 可以代表神经退行性疾病（如 PSP）的初始表现，而不是分化的疾病实体。 (C) 2007 年运动障碍协会。
Primary progressive freezing of gait (PPFG) is the term used to designate an uncommon condition featuring freezing of gait with frequent falls, without bradykinesia, rigidity or tremor, and unresponsive to levodopa. There are very few pathological reports of patients with PPFG in the literature. We report on 2 patients (one with pathological confirmation) diagnosed initially as PPFG and evolving into clinically defined progressive supranuclear palsy (PSP) more than 10 years after onset of symptoms. These 2 cases suggest that PPFG can represent the initial manifestation of a neurodegenerative disease, such as PSP, rather than a differentiated nosological entity. (C) 2007 Movement Disorder Society.