Apoptotic and non-apoptotic caspase functions in neural development

Apoptotic and non-apoptotic caspase functions in neural development
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神经发育中的凋亡和非凋亡 caspase 功能

DOI:
10.1007/s11064-010-0341-x
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发表时间:
2011
期刊:
Neurochemical Res
影响因子:
--
通讯作者:
M.
M.
中科院分区:
--
文献类型:
--
作者:
Miura;M.

文献摘要

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在神经发育过程中,脊椎动物和无脊椎动物都会发生大量细胞死亡。半胱天冬酶是细胞凋亡中进化保守的核心参与者。对果蝇和小鼠中caspase活性的遗传操作揭示了caspase通过凋亡和非凋亡机制控制细胞命运,以确保发育中的神经系统中适当的细胞分化和成熟。
During neural development, massive cell death occurs in both vertebrates and invertebrates. Caspase is a central player in apoptosis that is evolutionally conserved. Genetic manipulation of the caspase activity inDrosophilaand mice has revealed that caspases control cell fate through apoptotic and non-apoptotic mechanisms, to ensure appropriate cell differentiation and maturation in the developing nervous system.