Lutein and Zeaxanthin Supplementation and Association With Visual Function in Age-Related Macular Degeneration
Lutein and Zeaxanthin Supplementation and Association With Visual Function in Age-Related Macular Degeneration
复制标题
叶黄素和玉米黄质的补充及其与年龄相关性黄斑变性视觉功能的关系
DOI：
10.1167/iovs.14-15553
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发表时间：
2015-01-01
影响因子：
4.4
通讯作者：
Ma, Le
中科院分区：
文献类型：
--
作者：
Liu, Rong;Wang, Tian;Ma, Le
目的。在 AMD 患者的随机对照试验 (RCT) 中评估叶黄素和玉米黄质对视功能的影响。方法。截至 2014 年 4 月，通过对 PubMed、EMBASE、Web of Science 和 Cochrane 图书馆数据库的搜索确定了相关研究。三名研究人员独立确定了随机对照试验的资格，该随机对照试验将叶黄素和玉米黄质干预与安慰剂进行了比较。提取每项研究的调整加权平均差 (WMD)，以计算汇总估计值及其相应的 95% 置信区间 (CI)。主要结果测量包括视力（VA）、对比敏感度（CS）、眩光恢复时间（GRT）和视觉质量的主观感知。结果。荟萃分析中纳入了涉及 1176 名 AMD 患者的 8 项随机对照试验。与安慰剂组相比，叶黄素类胡萝卜素补充剂与 logMAR 水平显着降低相关（WMD，-0.04；95% CI，-0.06 至 -0.03），并且在干预期间，这些类胡萝卜素补充剂每增加 1 毫克/天，VA 的 logMAR 水平就会降低 0.003。与安慰剂相比，在 CS 的所有四个空间频率（WMD 范围为 0.08-0.18；所有 P < 0.05）上也观察到了显着的益处。此外，观察到干预后黄斑色素光密度的增加与 VA 的改善（r = -0.58；P = 0.02）以及 12 个周期/度的 CS 的改善之间存在关联（r = 0.94；P < 0.001）。结论。补充叶黄素和玉米黄质是改善AMD患者视觉功能的安全策略，主要表现在剂量-反应关系。
PURPOSE. To evaluate the effects of lutein and zeaxanthin on visual function in randomized controlled trials (RCTs) of AMD patients.METHODS. Relevant studies were identified by searches on PubMed, EMBASE, Web of Science, and Cochrane Library database up to April 2014. Three investigators independently determined the eligibility of RCTs, which compared lutein and zeaxanthin intervention with placebo. The adjusted weighted mean differences (WMDs) from each study were extracted to calculate a pooled estimate with its corresponding 95% confidence interval (CI). The main outcome measurements included visual acuity (VA), contrast sensitivity (CS), glare recovery time (GRT), and subjective perception of visual quality.RESULTS. Eight RCTs involving 1176 AMD patients were included in the meta-analysis. Xanthophyll carotenoids supplementation was associated with significant decrease in logMAR levels compared with the placebo group (WMD, -0.04; 95% CI, -0.06 to -0.03), and during intervention, each 1-mg/day increase in these carotenoids supplementation was related to a 0.003 reduction in logMAR level of VA. Remarkable benefit was also observed at all four spatial frequencies of CS (WMD ranging from 0.08-0.18; all P < 0.05) in contrast to placebo. Furthermore, association was observed between the postintervention increase in macular pigment optical density and improvements in VA (r = -0.58; P = 0.02), and in CS at 12 cycles/degree as well (r = 0.94; P < 0.001).CONCLUSIONS. Lutein and zeaxanthin supplementation is a safe strategy for improving visual performance of AMD patients, which mainly showed in a dose-response relationship.